ING1

ING1
Inhibidor de la proteína de crecimiento 1
HUGO 6062
Símbolo ING1
Símbolos alt. p24ING1c, p33, p33ING1, p33ING1b, p47, p47ING1a
Datos genéticos
Locus Cr. 13 q34
Bases de datos
Entrez 3621
OMIM 601566
RefSeq NP_005528
UniProt Q9UK53

El inhibidor de la proteína de crecimiento 1 (ING1) es una proteína codificada en humanos por el gen ing1.[1] [2] [3]

ING1 es una proteína supresora de tumores que puede inducir la parada del crecimiento celular y la apoptosis. Es una proteína nuclear que interacciona físicamente con la proteína supresora de tumores TP53 y es un intermediario de la vía de señalización p53. La reducción de la expresión o el reordenamiento de este gen han sido detectados en diversos tipos de cáncer. Se han descrito múltiples variantes transcripcionales que codifican distintas isoformas de la proteína ING1.[3]

El gen ing1 se encuentra localizado en el cromosoma 13, cerca de los siguientes genes:

  • CARKD: proteína con un dominio carbohidrato quinasa (función desconocida).
  • COL4A2: subunidad A2 del colágeno de tipo IV.
  • RAB20: regulador potencial del tráfico de la conexina 43.
  • CARS2: ARNt-cisteinil sintetasa mitocondrial 2.

Interacciones

La proteína ING1 ha demostrado ser capaz de interaccionar con:

Referencias

  1. Garkavtsev I, Kazarov A, Gudkov A, Riabowol K (Jan 1997). «Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation». Nat Genet 14 (4):  pp. 415–20. doi:10.1038/ng1296-415. PMID 8944021. 
  2. Garkavtsev I, Demetrick D, Riabowol K (Jul 1997). «Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1)». Cytogenet Cell Genet 76 (3-4):  pp. 176–8. PMID 9186514. 
  3. a b «Entrez Gene: ING1 inhibitor of growth family, member 1».
  4. a b Vieyra, Diego; Loewith Robbie, Scott Michelle, Bonnefin Paul, Boisvert Francois-Michel, Cheema Parneet, Pastyryeva Svitlana, Meijer Maria, Johnston Randal N, Bazett-Jones David P, McMahon Steven, Cole Michael D, Young Dallan, Riabowol Karl (Aug. 2002). «Human ING1 proteins differentially regulate histone acetylation». J. Biol. Chem. (United States) 277 (33):  pp. 29832–9. doi:10.1074/jbc.M200197200. ISSN 0021-9258. PMID 12015309. 
  5. a b c d e Kuzmichev, A; Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (Feb. 2002). «Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)». Mol. Cell. Biol. (United States) 22 (3):  pp. 835–48. ISSN 0270-7306. PMID 11784859. 
  6. Xin, Huawei; Yoon Ho-Guen, Singh Prim B, Wong Jiemin, Qin Jun (Mar. 2004). «Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells». J. Biol. Chem. (United States) 279 (10):  pp. 9539–46. doi:10.1074/jbc.M311587200. ISSN 0021-9258. PMID 14665632. 
  7. Scott, M; Bonnefin P, Vieyra D, Boisvert F M, Young D, Bazett-Jones D P, Riabowol K (Oct. 2001). «UV-induced binding of ING1 to PCNA regulates the induction of apoptosis». J. Cell. Sci. (England) 114 (Pt 19):  pp. 3455–62. ISSN 0021-9533. PMID 11682605. 
  8. Leung, Ka Man; Po Lai See, Tsang Fan Cheung, Siu Wai Yi, Lau Anita, Ho Horace T B, Poon Randy Y C (Sep. 2002). «The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2». Cancer Res. (United States) 62 (17):  pp. 4890–3. ISSN 0008-5472. PMID 12208736. 
  9. Garkavtsev, I; Grigorian I A, Ossovskaya V S, Chernov M V, Chumakov P M, Gudkov A V (Jan. 1998). «The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control». Nature (ENGLAND) 391 (6664):  pp. 295–8. doi:10.1038/34675. ISSN 0028-0836. PMID 9440684. 

Enlaces externos


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Mira otros diccionarios:

  • ING1 — Inhibitor of growth family, member 1, also known as ING1, is a human gene.cite web | title = Entrez Gene: ING1 inhibitor of growth family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=3621|… …   Wikipedia

  • -ing — ing1 a suffix of nouns formed from verbs, expressing the action of the verb or its result, product, material, etc. (the art of building; a new building; cotton wadding). It is also used to form nouns from words other than verbs (offing; shirting) …   Universalium

  • -ing — ing1 suffix 1》 denoting a verbal action, activity, or result: building. 2》 denoting material used for or associated with a process: piping. 3》 forming the gerund of verbs (such as painting as in I love painting). Origin OE ung, ing, of Gmc origin …   English new terms dictionary

  • ING2 — Inhibitor of growth family, member 2, also known as ING2, is a human gene.cite web | title = Entrez Gene: ING2 inhibitor of growth family, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=3622|… …   Wikipedia

  • Histona deacetilasa 1 — HUGO 4852 Símbolo HDAC1 Símbolos alt. DKFZp686H12203; GON 10; HD1; RPD3; RPD3L1 …   Wikipedia Español

  • lagging — I. /ˈlægɪŋ/ (say laging) noun the act of lagging behind. {lag1 + ing1} II. /ˈlægɪŋ/ (say laging) noun 1. the act of covering a boiler, etc., with heat insulating material. 2. the covering formed. 3. the material used. 4. ( …  

  • bank|ing — bank|ing1 «BANG kihng», noun. the business of keeping, lending, exchanging, and issuing money. ╂[< bank2 + ing1] bank|ing2 «BANG kihng», noun. 1. the construction of banks or embankments. 2. a bank or embankment. ╂[< …   Useful english dictionary

  • box|ing — box|ing1 «BOK sihng», noun. the action or sport of fighting with the fists. Boxers usually wear well padded leather gloves. ╂[< box2 + ing1] box|ing2 «BOK sihng», noun. 1. the material used for boxes. 2. the act or process of putting into or… …   Useful english dictionary

  • duck|ing — duck|ing1 «DUHK ihng», noun. 1. the act of plunging or being plunged into water. 2. immersion in water: »In colonial times, gossips were punished by ducking. 3. a sudden lowering of the head or body. ╂[< duck2 + ing1] duck|ing2 «DUHK ihng»,… …   Useful english dictionary

  • fair|ing — fair|ing1 «FAIR ihng», noun. an outer structure or surface of an aircraft or ship which reduces air or water resistance. ╂[< fair1, verb + ing1] fair|ing2 «FAIR ihng», noun. Archaic. 1. a present given at or brought from a fair: »Fairings were …   Useful english dictionary

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