PRPF6

PRPF6
PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)
HUGO 15860
Símbolo PRPF6
Símbolos alt. ANT-1; C20orf14; TOM; U5-102K; hPrp6
Bases de datos
Entrez 24148
RefSeq NP_036601

El factor 6 de procesamiento del pre-ARNm (PRPF6) es una proteína codificada en humanos por el gen PRPF6.[1] [2] [3]

La proteína codificada por este gen parece estar implicada en el proceso de splicing alternativo del pre-ARNm, posiblemente actuando como un factor puente entre los snRNPs U5 y U4/U6 en formación del espliceosoma. Esta proteína también puede unirse al receptor androgénico, proveyendo de un nexo de unión entre la activación transcripcional y el splicing.[3]

Interacciones

La proteína PRPF6 ha demostrado ser capaz de interaccionar con:

Referencias

  1. Nishikimi A, Mukai J, Kioka N, Yamada M (Jan 2000). «A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors». Biochim Biophys Acta 1435 (1-2):  pp. 147–52. PMID 10561546. 
  2. Makarov EM, Makarova OV, Achsel T, Luhrmann R (Jun 2000). «The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions». J Mol Biol 298 (4):  pp. 567–75. doi:10.1006/jmbi.2000.3685. PMID 10788320. 
  3. a b «Entrez Gene: PRPF6 PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)».
  4. Sun, Xiaojing; Zhang Hua, Wang Dan, Ma Dalong, Shen Yan, Shang Yongfeng (Jul. 2004). «DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression». J. Biol. Chem. (United States) 279 (31):  pp. 32839–47. doi:10.1074/jbc.M402522200. ISSN 0021-9258. PMID 15161931. 
  5. Yuryev, Anton; Wennogle Lawrence P (Feb. 2003). «Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis». Genomics (United States) 81 (2):  pp. 112–25. ISSN 0888-7543. PMID 12620389. 
  6. Yuryev, A; Ono M, Goff S A, Macaluso F, Wennogle L P (Jul. 2000). «Isoform-specific localization of A-RAF in mitochondria». Mol. Cell. Biol. (UNITED STATES) 20 (13):  pp. 4870–8. ISSN 0270-7306. PMID 10848612. 
  7. Zhao, Yue; Goto Kiminobu, Saitoh Masayuki, Yanase Toshihiko, Nomura Masatoshi, Okabe Taijiro, Takayanagi Ryoichi, Nawata Hajime (Aug. 2002). «Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor». J. Biol. Chem. (United States) 277 (33):  pp. 30031–9. doi:10.1074/jbc.M203811200. ISSN 0021-9258. PMID 12039962. 

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