- TAS2R38
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TAS2R38 es un receptor de gusto amargo[1] [2] que facilita la percepción del sabor de la feniltiocarbamida (PTC, por su sigla en inglés)[3] y propiltiouracilo (PROP),[4] aunque no explica a los supertasters.[5] Los portadores del alelo PAV experiencian más amargura en los vegetales[6] y los consumen menos frecuentemente y en menor cantidad.[7]
Contenido
Referencias
- ↑ Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ (2002). «Identification and characterization of human taste receptor genes belonging to the TAS2R family». Cytogenet. Genome Res. 98 (1): pp. 45–53. doi:. PMID 12584440.
- ↑ Drayna D, Coon H, Kim UK, Elsner T, Cromer K, Otterud B, Baird L, Peiffer AP, Leppert M (2003). «Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p». Hum. Genet. 112 (5-6): pp. 567–72. doi:. PMID 12624758.
- ↑ Prodi DA, Drayna D, Forabosco P, Palmas MA, Maestrale GB, Piras D, Pirastu M, Angius A (2004). «Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene». Chem. Senses 29 (8): pp. 697–702. doi:. PMID 15466815.
- ↑ Duffy VB, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, Reed DR, Snyder DJ, Bartoshuk LM (2004). «Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake». Alcohol. Clin. Exp. Res. 28 (11): pp. 1629–37. doi:. PMID 15547448.
- ↑ Hayes JE, Bartoshuk LM, Kidd JR, Duffy VB (2008). «Supertasting and PROP Bitterness Depends on More Than the TAS2R38 Gene». Chem Senses 33 (3): pp. 255–65. doi:. PMID 18209019.
- ↑ (Sandell & Breslin 2006)
- ↑ (Duffy et al 2010)
Lectura complementaria
- Margolskee RF (2002). «Molecular mechanisms of bitter and sweet taste transduction.». J. Biol. Chem. 277 (1): pp. 1–4. doi:. PMID 11696554.
- Montmayeur JP, Matsunami H (2002). «Receptors for bitter and sweet taste.». Curr. Opin. Neurobiol. 12 (4): pp. 366–71. doi:. PMID 12139982.
- Kim UK, Drayna D (2005). «Genetics of individual differences in bitter taste perception: lessons from the PTC gene.». Clin. Genet. 67 (4): pp. 275–80. doi:. PMID 15733260.
- Anne-Spence M, Falk CT, Neiswanger K, et al. (1984). «Estimating the recombination frequency for the PTC-Kell linkage.». Hum. Genet. 67 (2): pp. 183–6. doi:. PMID 6745938.
- Bufe B, Hofmann T, Krautwurst D, et al. (2002). «The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.». Nat. Genet. 32 (3): pp. 397–401. doi:. PMID 12379855.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): pp. 16899–903. doi:. PMID 12477932.
- Zhang Y, Hoon MA, Chandrashekar J, et al. (2003). «Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.». Cell 112 (3): pp. 293–301. doi:. PMID 12581520.
- Conte C, Ebeling M, Marcuz A, et al. (2003). «Identification and characterization of human taste receptor genes belonging to the TAS2R family.». Cytogenet. Genome Res. 98 (1): pp. 45–53. doi:. PMID 12584440.
- Kim UK, Jorgenson E, Coon H, et al. (2003). «Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide.». Science 299 (5610): pp. 1221–5. doi:. PMID 12595690.
- Drayna D, Coon H, Kim UK, et al. (2003). «Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p.». Hum. Genet. 112 (5-6): pp. 567–72. doi:. PMID 12624758.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). «Human chromosome 7: DNA sequence and biology.». Science 300 (5620): pp. 767–72. doi:. PMID 12690205.
- Wooding S, Kim UK, Bamshad MJ, et al. (2004). «Natural selection and molecular evolution in PTC, a bitter-taste receptor gene.». Am. J. Hum. Genet. 74 (4): pp. 637–46. doi:. PMID 14997422.
- Pronin AN, Tang H, Connor J, Keung W (2005). «Identification of ligands for two human bitter T2R receptors.». Chem. Senses 29 (7): pp. 583–93. doi:. PMID 15337684.
- Prodi DA, Drayna D, Forabosco P, et al. (2005). «Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene.». Chem. Senses 29 (8): pp. 697–702. doi:. PMID 15466815.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res. 14 (10B): pp. 2121–7. doi:. PMID 15489334.
- Fischer A, Gilad Y, Man O, Pääbo S (2005). «Evolution of bitter taste receptors in humans and apes.». Mol. Biol. Evol. 22 (3): pp. 432–6. doi:. PMID 15496549.
- Go Y, Satta Y, Takenaka O, Takahata N (2006). «Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.». Genetics 170 (1): pp. 313–26. doi:. PMID 15744053.
Véase también
- Supertaster
Enlaces externos
Categorías:- Genes
- Receptores acoplados a proteínas G
- Receptores transmembrana
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