DSCAM

DSCAM

DSCAM

DSCAM y Dscam son acrónimos de Down Syndrome Cell Adhesión Molecule. DSCAM hace referencia al gen humano mientras que Dscam hace referencia al gen de Drosophila (análogo al humano).

Las DSCAM son una nueva clase de moléculas de adhesión de las células neuronales y pertenecen a una superfamilia de inmunoglobulinas.

Como curiosidad cabe destacar que la Dscam, el análogo en Drosophila del gen DSCAM de humanos, ostenta el record de sitios de splicing alternativo con 38.000 sitios posibles.

Referencias

  1. Schmucker D, Clemens JC, Shu H, Worby CA, Xiao J, Muda M, Dixon JE, Zipursky SL (2000) Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell. 2000 Jun 9;101(6):671-84. Entrez PubMed 10892653
  2. Li W, Guan KL (2004) The Down Syndrome Cell Adhesión Molecule (DSCAM) Interacts with and Activates Pak J Biol Chem. 2004 Jul 30;279(31):32824-31. Epub 2004 May 28. Entrez PubMed 15169762
  3. Wojtowicz WM, Flanagan JJ, Millard SS, Zipursky SL, Clemens JC. (2004) Alternative splicing of Drosophila Dscam generates axon guidance receptors that exhibit isoform-specific homophilic binding. Cell. 2004 Sep 3;118(5):619-33. Entrez PubMed 15339666
  4. Watson FL, Puttmann-Holgado R, Thomas F, Lamar DL, Hughes M, Kondo M, Rebel VI, Schmucker D (2005) Extensive diversity of Ig-superfamily proteins in the immune system of insects. Science. 2005 Sep 16;309(5742):1874-8. Epub 2005 Aug 18. Entrez PubMed 16109846
  5. Chen BE, Kondo M, Garnier A, Watson FL, Puettmann-Holgado R, Lamar DR, Schmucker D. (2006) The molecular diversity of Dscam is functionally required for neuronal wiring specificity in Drosophila. Cell. 2006 May 5;125(3):607-20. Entrez PubMed 16678102
Obtenido de "DSCAM"

Wikimedia foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Mira otros diccionarios:

  • DSCAM — and Dscam are both abbreviations for Down Syndrome Cell Adhesion Molecule. The case difference is significant: DSCAM refers to the human protein, and Dscam refers to its analog in Drosophila. Of particular interest is that Dscam1 could… …   Wikipedia

  • Иммунология насекомых — Иммунология насекомых  отрасль иммунологии изучающая иммунитет насекомых. Содержание 1 Иммунитет насекомых  общие сведения 2 …   Википедия

  • Alternative splicing — produces two protein isoforms. Alternative splicing (or differential splicing) is a process by which the exons of the RNA produced by transcription of a gene (a primary gene transcript or pre mRNA) are reconnected in multiple ways during RNA… …   Wikipedia

  • Spliceosome — A spliceosome is a complex of specialized RNA and protein subunits that removes introns from a transcribed pre mRNA (hnRNA)segment. This process is generally referred to as splicing. CompositionEach spliceosome is composed of five small nuclear… …   Wikipedia

  • Common misunderstandings of genetics — “ Indeed there is a popular dogma that is reinforced daily in the media and, it must be said, by many scientists that rests on a crude mistake... André Pichot has called this DNA mania.[1] ” …   Wikipedia

  • Acronym and initialism — For acronyms used on Wikipedia, see Wikipedia:Acronyms. Acronyms and initialisms are abbreviations formed from the initial components in a phrase or name. These components may be individual letters (as in CEO) or parts of words (as in Benelux and …   Wikipedia

  • Alternatives Spleißen — Schematische Darstellung von alternativem Splicing mittels exon skipping. Das Alternative Spleißen (auch differenzielles oder gewebespezifisches Spleißen genannt) stellt einen besonderen Vorgang im Rahmen der Transkription bei Eukaryoten dar.… …   Deutsch Wikipedia

  • Alternatives Splicing — Dieser Artikel oder Abschnitt ist nicht hinreichend mit Belegen (Literatur, Webseiten oder Einzelnachweisen) versehen. Die fraglichen Angaben werden daher möglicherweise demnächst gelöscht. Hilf Wikipedia, indem du die Angaben recherchierst und… …   Deutsch Wikipedia

  • Epissage — Épissage Chez les eucaryotes (organismes dont les cellules possèdent un noyau), l’épissage (ou épissure) est un processus par lequel les ARN transcrits à partir de l ADN génomique peuvent subir des étapes de coupure et ligature qui conduisent à… …   Wikipédia en Français

  • Epissage (génétique) — Épissage Chez les eucaryotes (organismes dont les cellules possèdent un noyau), l’épissage (ou épissure) est un processus par lequel les ARN transcrits à partir de l ADN génomique peuvent subir des étapes de coupure et ligature qui conduisent à… …   Wikipédia en Français

Compartir el artículo y extractos

Link directo
… Do a right-click on the link above
and select “Copy Link”