DSCAM

DSCAM

DSCAM

DSCAM y Dscam son acrónimos de Down Syndrome Cell Adhesión Molecule. DSCAM hace referencia al gen humano mientras que Dscam hace referencia al gen de Drosophila (análogo al humano).

Las DSCAM son una nueva clase de moléculas de adhesión de las células neuronales y pertenecen a una superfamilia de inmunoglobulinas.

Como curiosidad cabe destacar que la Dscam, el análogo en Drosophila del gen DSCAM de humanos, ostenta el record de sitios de splicing alternativo con 38.000 sitios posibles.

Referencias

  1. Schmucker D, Clemens JC, Shu H, Worby CA, Xiao J, Muda M, Dixon JE, Zipursky SL (2000) Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell. 2000 Jun 9;101(6):671-84. Entrez PubMed 10892653
  2. Li W, Guan KL (2004) The Down Syndrome Cell Adhesión Molecule (DSCAM) Interacts with and Activates Pak J Biol Chem. 2004 Jul 30;279(31):32824-31. Epub 2004 May 28. Entrez PubMed 15169762
  3. Wojtowicz WM, Flanagan JJ, Millard SS, Zipursky SL, Clemens JC. (2004) Alternative splicing of Drosophila Dscam generates axon guidance receptors that exhibit isoform-specific homophilic binding. Cell. 2004 Sep 3;118(5):619-33. Entrez PubMed 15339666
  4. Watson FL, Puttmann-Holgado R, Thomas F, Lamar DL, Hughes M, Kondo M, Rebel VI, Schmucker D (2005) Extensive diversity of Ig-superfamily proteins in the immune system of insects. Science. 2005 Sep 16;309(5742):1874-8. Epub 2005 Aug 18. Entrez PubMed 16109846
  5. Chen BE, Kondo M, Garnier A, Watson FL, Puettmann-Holgado R, Lamar DR, Schmucker D. (2006) The molecular diversity of Dscam is functionally required for neuronal wiring specificity in Drosophila. Cell. 2006 May 5;125(3):607-20. Entrez PubMed 16678102
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