Coactivador de receptor nuclear 1
Protein NCOA1 PDB 1oj5.png
Estructura tridimensional de la proteína NCOA1.
HUGO 7668
Símbolo NCOA1
Símbolos alt. SRC1; F-SRC-1; MGC129719; MGC129720; NCoA-1; RIP160
Datos genéticos
Locus Cr. 2 p23.3
Bases de datos
Entrez 8648
OMIM 602691
PDB 1oj5
RefSeq NP_003734
UniProt Q15788

El coactivador de receptor nuclear 1 (NCOA1 o SRC-1) es una proteína codificada en humanos por el gen NCOA1.

La proteínas NCOA1 es un corregulador transcripcional que contiene varios dominios de interacción con receptores nucleares y una actividad histona acetiltransferasa intrínseca. NCOA1 es reclutado hacia ciertos promotores del ADN por receptores nucleares activados por ligando. Esta proteína acila histonas promoviendo que al ADN sea más accesible a la transcripción. De hecho, NCOA1 ayuda a los receptores nucleares en la activación de la expresión génica.[1] [2]


La proteína NCOA1 ha demostrado ser capaz de interaccionar con:


  1. Onate SA, Tsai SY, Tsai MJ, O'Malley BW (1995). «Sequence and characterization of a coactivator for the steroid hormone receptor superfamily». Science 270 (5240):  pp. 1354–7. doi:10.1126/science.270.5240.1354. PMID 7481822. 
  2. Onate SA, Boonyaratanakornkit V, Spencer TE, Tsai SY, Tsai MJ, Edwards DP, O'Malley BW (1998). «The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors». J Biol Chem 273 (20):  pp. 12101–8. doi:10.1074/jbc.273.20.12101. PMID 9575154. 
  3. Liu, Y; Takeshita A, Misiti S, Chin W W, Yen P M (Oct. 1998). «Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors». Endocrinology (UNITED STATES) 139 (10):  pp. 4197–204. ISSN 0013-7227. PMID 9751500. 
  4. Jeyakumar, M; Tanen M R, Bagchi M K (Jun. 1997). «Analysis of the functional role of steroid receptor coactivator-1 in ligand-induced transactivation by thyroid hormone receptor». Mol. Endocrinol. (UNITED STATES) 11 (6):  pp. 755–67. ISSN 0888-8809. PMID 9171239. 
  5. Tzortzakaki, Eleni; Spilianakis Charalambos, Zika Eleni, Kretsovali Androniki, Papamatheakis Joseph (Dec. 2003). «Steroid receptor coactivator 1 links the steroid and interferon gamma response pathways». Mol. Endocrinol. (United States) 17 (12):  pp. 2509–18. doi:10.1210/me.2002-0439. ISSN 0888-8809. PMID 12933903. 
  6. a b c Watanabe, M; Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S (Mar. 2001). «A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA». EMBO J. (England) 20 (6):  pp. 1341–52. doi:10.1093/emboj/20.6.1341. ISSN 0261-4189. PMID 11250900. 
  7. Zhang, C; Baudino T A, Dowd D R, Tokumaru H, Wang W, MacDonald P N (Nov. 2001). «Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription». J. Biol. Chem. (United States) 276 (44):  pp. 40614–20. doi:10.1074/jbc.M106263200. ISSN 0021-9258. PMID 11514567. 
  8. Masiello, David; Chen Shao-Yong, Xu Youyuan, Verhoeven Manon C, Choi Eunis, Hollenberg Anthony N, Balk Steven P (Oct. 2004). «Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells». Mol. Endocrinol. (United States) 18 (10):  pp. 2388–401. doi:10.1210/me.2003-0436. ISSN 0888-8809. PMID 15256534. 
  9. Ueda, Takeshi; Mawji Nasrin R, Bruchovsky Nicholas, Sadar Marianne D (Oct. 2002). «Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells». J. Biol. Chem. (United States) 277 (41):  pp. 38087–94. doi:10.1074/jbc.M203313200. ISSN 0021-9258. PMID 12163482. 
  10. Bevan, C L; Hoare S, Claessens F, Heery D M, Parker M G (Dec. 1999). «The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1». Mol. Cell. Biol. (UNITED STATES) 19 (12):  pp. 8383–92. ISSN 0270-7306. PMID 10567563. 
  11. Giraud, Sandrine; Bienvenu Frédéric, Avril Sylvie, Gascan Hugues, Heery David M, Coqueret Olivier (Mar. 2002). «Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a». J. Biol. Chem. (United States) 277 (10):  pp. 8004–11. doi:10.1074/jbc.M111486200. ISSN 0021-9258. PMID 11773079. 
  12. a b Sheppard, H M; Harries J C, Hussain S, Bevan C, Heery D M (Jan. 2001). «Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1». Mol. Cell. Biol. (UNITED STATES) 21 (1):  pp. 39–50. doi:10.1128/MCB.21.1.39-50.2001. ISSN 0270-7306. PMID 11113179. 
  13. Wu, Ray-Chang; Qin Jun, Hashimoto Yoshihiro, Wong Jiemin, Xu Jianming, Tsai Sophia Y, Tsai Ming-Jer, O'Malley Bert W (May. 2002). «Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase». Mol. Cell. Biol. (United States) 22 (10):  pp. 3549–61. ISSN 0270-7306. PMID 11971985. 
  14. Zilliacus, J; Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson J A (Apr. 2001). «Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140». Mol. Endocrinol. (United States) 15 (4):  pp. 501–11. ISSN 0888-8809. PMID 11266503. 
  15. Kucera, Tomas; Waltner-Law Mary, Scott Donald K, Prasad Ratna, Granner Daryl K (Jul. 2002). «A point mutation of the AF2 transactivation domain of the glucocorticoid receptor disrupts its interaction with steroid receptor coactivator 1». J. Biol. Chem. (United States) 277 (29):  pp. 26098–102. doi:10.1074/jbc.M204013200. ISSN 0021-9258. PMID 12118039. 
  16. Dowell, P; Ishmael J E, Avram D, Peterson V J, Nevrivy D J, Leid M (Dec. 1997). «p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha». J. Biol. Chem. (UNITED STATES) 272 (52):  pp. 33435–43. ISSN 0021-9258. PMID 9407140. 
  17. Treuter, E; Albrektsen T, Johansson L, Leers J, Gustafsson J A (Jun. 1998). «A regulatory role for RIP140 in nuclear receptor activation». Mol. Endocrinol. (UNITED STATES) 12 (6):  pp. 864–81. ISSN 0888-8809. PMID 9626662. 
  18. Kim, H J; Yi J Y, Sung H S, Moore D D, Jhun B H, Lee Y C, Lee J W (Sep. 1999). «Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation». Mol. Cell. Biol. (UNITED STATES) 19 (9):  pp. 6323–32. ISSN 0270-7306. PMID 10454579. 
  19. a b c Lee, S K; Na S Y, Jung S Y, Choi J E, Jhun B H, Cheong J, Meltzer P S, Lee Y C, Lee J W (Jun. 2000). «Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2». Mol. Endocrinol. (UNITED STATES) 14 (6):  pp. 915–25. ISSN 0888-8809. PMID 10847592. 
  20. a b Lee, S K; Kim H J, Na S Y, Kim T S, Choi H S, Im S Y, Lee J W (Jul. 1998). «Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits». J. Biol. Chem. (UNITED STATES) 273 (27):  pp. 16651–4. ISSN 0021-9258. PMID 9642216. 
  21. Litterst, C M; Pfitzner E (Dec. 2001). «Transcriptional activation by STAT6 requires the direct interaction with NCoA-1». J. Biol. Chem. (United States) 276 (49):  pp. 45713–21. doi:10.1074/jbc.M108132200. ISSN 0021-9258. PMID 11574547. 
  22. Litterst, Claudia M; Pfitzner Edith (Sep. 2002). «An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1». J. Biol. Chem. (United States) 277 (39):  pp. 36052–60. doi:10.1074/jbc.M203556200. ISSN 0021-9258. PMID 12138096. 
  23. Spencer, T E; Jenster G, Burcin M M, Allis C D, Zhou J, Mizzen C A, McKenna N J, Onate S A, Tsai S Y, Tsai M J, O'Malley B W (Sep. 1997). «Steroid receptor coactivator-1 is a histone acetyltransferase». Nature (ENGLAND) 389 (6647):  pp. 194–8. doi:10.1038/38304. ISSN 0028-0836. PMID 9296499. 
  24. Puigserver, P; Adelmant G, Wu Z, Fan M, Xu J, O'Malley B, Spiegelman B M (Nov. 1999). «Activation of PPARgamma coactivator-1 through transcription factor docking». Science (UNITED STATES) 286 (5443):  pp. 1368–71. ISSN 0036-8075. PMID 10558993. 
  25. Na, S Y; Lee S K, Han S J, Choi H S, Im S Y, Lee J W (May. 1998). «Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kappaB-mediated transactivations». J. Biol. Chem. (UNITED STATES) 273 (18):  pp. 10831–4. ISSN 0021-9258. PMID 9556555. 
  26. Zwijsen, R M; Buckle R S, Hijmans E M, Loomans C J, Bernards R (Nov. 1998). «Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1». Genes Dev. (UNITED STATES) 12 (22):  pp. 3488–98. ISSN 0890-9369. PMID 9832502. 
  27. DiRenzo, J; Shang Y, Phelan M, Sif S, Myers M, Kingston R, Brown M (Oct. 2000). «BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation». Mol. Cell. Biol. (UNITED STATES) 20 (20):  pp. 7541–9. ISSN 0270-7306. PMID 11003650. 
  28. Kalkhoven, E; Valentine J E, Heery D M, Parker M G (Jan. 1998). «Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor». EMBO J. (ENGLAND) 17 (1):  pp. 232–43. doi:10.1093/emboj/17.1.232. ISSN 0261-4189. PMID 9427757. 
  29. Kang, Yun Kyoung; Guermah Mohamed, Yuan Chao-Xing, Roeder Robert G (Mar. 2002). «The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro». Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (5):  pp. 2642–7. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMID 11867769. 
  30. Lee, S K; Anzick S L, Choi J E, Bubendorf L, Guan X Y, Jung Y K, Kallioniemi O P, Kononen J, Trent J M, Azorsa D, Jhun B H, Cheong J H, Lee Y C, Meltzer P S, Lee J W (Nov. 1999). «A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo». J. Biol. Chem. (UNITED STATES) 274 (48):  pp. 34283–93. ISSN 0021-9258. PMID 10567404. 

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