NCOR1

NCOR1
Correpresor 1 de receptor nuclear
HUGO 7672
Símbolo NCOR1
Símbolos alt. KIAA1047; MGC104216; N-CoR; TRAC1; hCIT529I10; hN-CoR
Datos genéticos
Locus Cr. 17 p12-p11.2
Bases de datos
Entrez 9611
OMIM 600849
RefSeq XP_001133522
UniProt O75376

El correpresor 1 de receptor nuclear (NCOR1) es un corregulador transcripcional codificado en humanos por el gen ncor1, que contiene varios dominios de interacción con receptores nucleares. Además, NCOR1 parece estar implicado en el reclutamiento de las histona deacetilasas hacia regiones promotoras en el ADN. De hecho, NCOR1 ayuda a los receptores nucleares en la regulación de la expresión génica.[1] [2] NCOR1 también suele ser denominado como correpresor 1 asociado a hormona tiroidea y receptor de ácido retinoico (TRAC-1).

Interacciones

La proteína NCOR1 ha demostrado ser capaz de interaccionar con:

Referencias

  1. ↑ Horlein AJ, Naar AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Soderstrom M, Glass CK, Rosenfeld MG (1998). «Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor». Nature 377 (6548):  pp. 397–404. doi:10.1038/377397a0. PMID 7566114. 
  2. ↑ Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM (1998). «ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex». Proc Natl Acad Sci USA 95 (18):  pp. 10860–5. doi:10.1073/pnas.95.18.10860. PMID 9724795. 
  3. ↑ Petrie, Kevin; Guidez Fabien, Howell Louise, Healy Lyn, Waxman Samuel, Greaves Mel, Zelent Arthur (May. 2003). «The histone deacetylase 9 gene encodes multiple protein isoforms». J. Biol. Chem. (United States) 278 (18):  pp. 16059–72. doi:10.1074/jbc.M212935200. ISSN 0021-9258. PMID 12590135. 
  4. ↑ Tai, Helen H; Geisterfer Margit, Bell John C, Moniwa Mariko, Davie James R, Boucher Lorrie, McBurney Michael W (Aug. 2003). «CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins». Biochem. Biophys. Res. Commun. (United States) 308 (1):  pp. 170–6. ISSN 0006-291X. PMID 12890497. 
  5. ↑ a b Fischle, W; Dequiedt F, Fillion M, Hendzel M J, Voelter W, Verdin E (Sep. 2001). «Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo». J. Biol. Chem. (United States) 276 (38):  pp. 35826–35. doi:10.1074/jbc.M104935200. ISSN 0021-9258. PMID 11466315. 
  6. ↑ Baek, Sung Hee; Ohgi Kenneth A, Rose David W, Koo Edward H, Glass Christopher K, Rosenfeld Michael G (Jul. 2002). «Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein». Cell (United States) 110 (1):  pp. 55–67. ISSN 0092-8674. PMID 12150997. 
  7. ↑ Stevens, Adam; Garside Helen, Berry Andrew, Waters Charlotte, White Anne, Ray David (May. 2003). «Dissociation of steroid receptor coactivator 1 and nuclear receptor corepressor recruitment to the human glucocorticoid receptor by modification of the ligand-receptor interface: the role of tyrosine 735». Mol. Endocrinol. (United States) 17 (5):  pp. 845–59. doi:10.1210/me.2002-0320. ISSN 0888-8809. PMID 12569182. 
  8. ↑ Schulz, Martin; Eggert Martin, Baniahmad Aria, Dostert Anja, Heinzel Thorsten, Renkawitz Rainer (Jul. 2002). «RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding». J. Biol. Chem. (United States) 277 (29):  pp. 26238–43. doi:10.1074/jbc.M203268200. ISSN 0021-9258. PMID 12011091. 
  9. ↑ Kokura, K; Kaul S C, Wadhwa R, Nomura T, Khan M M, Shinagawa T, Yasukawa T, Colmenares C, Ishii S (Sep. 2001). «The Ski protein family is required for MeCP2-mediated transcriptional repression». J. Biol. Chem. (United States) 276 (36):  pp. 34115–21. doi:10.1074/jbc.M105747200. ISSN 0021-9258. PMID 11441023. 
  10. ↑ a b c Dowell, P; Ishmael J E, Avram D, Peterson V J, Nevrivy D J, Leid M (May. 1999). «Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein». J. Biol. Chem. (UNITED STATES) 274 (22):  pp. 15901–7. ISSN 0021-9258. PMID 10336495. 
  11. ↑ Iso, T; Sartorelli V, Poizat C, Iezzi S, Wu H Y, Chung G, Kedes L, Hamamori Y (Sep. 2001). «HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling». Mol. Cell. Biol. (United States) 21 (17):  pp. 6080–9. ISSN 0270-7306. PMID 11486045. 
  12. ↑ a b c d e Zhang, Jinsong; Kalkum Markus, Chait Brian T, Roeder Robert G (Mar. 2002). «The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2». Mol. Cell (United States) 9 (3):  pp. 611–23. ISSN 1097-2765. PMID 11931768. 
  13. ↑ a b Huang, E Y; Zhang J, Miska E A, Guenther M G, Kouzarides T, Lazar M A (Jan. 2000). «Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway». Genes Dev. (UNITED STATES) 14 (1):  pp. 45–54. ISSN 0890-9369. PMID 10640275. 
  14. ↑ a b c d Yoon, Ho-Geun; Chan Doug W, Reynolds Albert B, Qin Jun, Wong Jiemin (Sep. 2003). «N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso». Mol. Cell (United States) 12 (3):  pp. 723–34. ISSN 1097-2765. PMID 14527417. 
  15. ↑ a b c d Yoon, Ho-Geun; Chan Doug W, Huang Zhi-Qing, Li Jiwen, Fondell Joseph D, Qin Jun, Wong Jiemin (Mar. 2003). «Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1». EMBO J. (England) 22 (6):  pp. 1336–46. doi:10.1093/emboj/cdg120. ISSN 0261-4189. PMID 12628926. 
  16. ↑ a b Li, J; Wang J, Wang J, Nawaz Z, Liu J M, Qin J, Wong J (Aug. 2000). «Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3». EMBO J. (ENGLAND) 19 (16):  pp. 4342–50. doi:10.1093/emboj/19.16.4342. ISSN 0261-4189. PMID 10944117. 
  17. ↑ Guenther, M G; Lane W S, Fischle W, Verdin E, Lazar M A, Shiekhattar R (May. 2000). «A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness». Genes Dev. (UNITED STATES) 14 (9):  pp. 1048–57. ISSN 0890-9369. PMID 10809664. 
  18. ↑ a b Fischle, Wolfgang; Dequiedt Franck, Hendzel Michael J, Guenther Matthew G, Lazar Mitchell A, Voelter Wolfgang, Verdin Eric (Jan. 2002). «Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR». Mol. Cell (United States) 9 (1):  pp. 45–57. ISSN 1097-2765. PMID 11804585. 
  19. ↑ a b Underhill, C; Qutob M S, Yee S P, Torchia J (Dec. 2000). «A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1». J. Biol. Chem. (UNITED STATES) 275 (51):  pp. 40463–70. doi:10.1074/jbc.M007864200. ISSN 0021-9258. PMID 11013263. 
  20. ↑ Guidez, F; Ivins S, Zhu J, Söderström M, Waxman S, Zelent A (Apr. 1998). «Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia». Blood (UNITED STATES) 91 (8):  pp. 2634–42. ISSN 0006-4971. PMID 9531570. 
  21. ↑ Laherty, C D; Billin A N, Lavinsky R M, Yochum G S, Bush A C, Sun J M, Mullen T M, Davie J R, Rose D W, Glass C K, Rosenfeld M G, Ayer D E, Eisenman R N (Jul. 1998). «SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors». Mol. Cell (UNITED STATES) 2 (1):  pp. 33–42. ISSN 1097-2765. PMID 9702189. 
  22. ↑ Masiello, David; Chen Shao-Yong, Xu Youyuan, Verhoeven Manon C, Choi Eunis, Hollenberg Anthony N, Balk Steven P (Oct. 2004). «Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells». Mol. Endocrinol. (United States) 18 (10):  pp. 2388–401. doi:10.1210/me.2003-0436. ISSN 0888-8809. PMID 15256534. 
  23. ↑ Song, Liang-Nian; Coghlan Meghan, Gelmann Edward P (Jan. 2004). «Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor». Mol. Endocrinol. (United States) 18 (1):  pp. 70–85. doi:10.1210/me.2003-0189. ISSN 0888-8809. PMID 14593076. 
  24. ↑ Cheng, Shinta; Brzostek Sabrina, Lee Suzanne R, Hollenberg Anthony N, Balk Steven P (Jul. 2002). «Inhibition of the dihydrotestosterone-activated androgen receptor by nuclear receptor corepressor». Mol. Endocrinol. (United States) 16 (7):  pp. 1492–501. ISSN 0888-8809. PMID 12089345. 
  25. ↑ Hodgson, Myles C; Astapova Inna, Cheng Shinta, Lee Larissa J, Verhoeven Manon C, Choi Eunis, Balk Steven P, Hollenberg Anthony N (Feb. 2005). «The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists». J. Biol. Chem. (United States) 280 (8):  pp. 6511–9. doi:10.1074/jbc.M408972200. ISSN 0021-9258. PMID 15598662. 
  26. ↑ Amann, J M; Nip J, Strom D K, Lutterbach B, Harada H, Lenny N, Downing J R, Meyers S, Hiebert S W (Oct. 2001). «ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain». Mol. Cell. Biol. (United States) 21 (19):  pp. 6470–83. ISSN 0270-7306. PMID 11533236. 
  27. ↑ Zhang, J; Hug B A, Huang E Y, Chen C W, Gelmetti V, Maccarana M, Minucci S, Pelicci P G, Lazar M A (Jan. 2001). «Oligomerization of ETO is obligatory for corepressor interaction». Mol. Cell. Biol. (UNITED STATES) 21 (1):  pp. 156–63. doi:10.1128/MCB.21.1.156-163.2001. ISSN 0270-7306. PMID 11113190. 
  28. ↑ Puccetti, Elena; Obradovic Darja, Beissert Tim, Bianchini Andrea, Washburn Birgit, Chiaradonna Ferdinando, Boehrer Simone, Hoelzer Dieter, Ottmann Oliver Gerhard, Pelicci Pier Giuseppe, Nervi Clara, Ruthardt Martin (Dec. 2002). «AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor». Cancer Res. (United States) 62 (23):  pp. 7050–8. ISSN 0008-5472. PMID 12460926. 
  29. ↑ Tagami, T; Lutz W H, Kumar R, Jameson J L (Dec. 1998). «The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators». Biochem. Biophys. Res. Commun. (UNITED STATES) 253 (2):  pp. 358–63. doi:10.1006/bbrc.1998.9799. ISSN 0006-291X. PMID 9878542. 
  30. ↑ Khan, M M; Nomura T, Kim H, Kaul S C, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi P P, Ishii S (Jun. 2001). «Role of PML and PML-RARalpha in Mad-mediated transcriptional repression». Mol. Cell (United States) 7 (6):  pp. 1233–43. ISSN 1097-2765. PMID 11430826. 

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