NRIP1

NRIP1
Proteína de interacción con receptores nucleares 1
HUGO 8001
Símbolo NRIP1
Símbolos alt. RIP140
Datos genéticos
Locus Cr. 21 q11.2
Bases de datos
Entrez 8204
OMIM 602490
RefSeq NP_003480
UniProt P48552

La proteína de interacción con receptores nucleares 1 (NRIP1) es una proteína que es codificada en humanos por el gen nrip1.[1] [2]

NRIP1 es una proteína nuclear que interacciona específicamente con el dominio de activación AF2 dependiente de hormona de receptores nucleares. También es conocida como RIP140. Esta proteína modula la actividad transcripcional del receptor de estrógeno.[3] Estudios llevados a cabo en ratones knockout para el gen nrip1 demostró que los ratones se quedaban delgados incluso siendo alimentados con una dieta rica. NRIP1 forma parte del proceso por el cual un tumor puede causar caquexia.[4] [5] Parece ser que el principal papel de NRIP1 se encuentra en el tejido adiposo bloqueando la expresión de aquellos genes implicados en la disipación de energía y en el desacople mitocondrial, como pueden ser los que codifican la proteína desacopladora 1 y la carnitina palmitoiltransferasa 1b.[6]

Contenido

Interacciones

La proteína NRIP1 ha demostrado ser capaz de interaccionar con:

Véase también

  • Corregulador transcripcional

Enlaces externos

Referencias

  1. ↑ a b Cavailles V, Dauvois S, L'Horset F, Lopez G, Hoare S, Kushner PJ, Parker MG (Sep 1995). «Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor». EMBO J 14 (15):  pp. 3741–51. PMID 7641693. 
  2. ↑ Katsanis N, Ives JH, Groet J, Nizetic D, Fisher EM (Apr 1998). «Localisation of receptor interacting protein 140 (RIP140) within 100 kb of D21S13 on 21q11, a gene-poor region of the human genome». Hum Genet 102 (2):  pp. 221–3. PMID 9521594. 
  3. ↑ «Entrez Gene: NRIP1 nuclear receptor interacting protein 1».
  4. ↑ «A common denominator of inflammations and fatty liver». News. Science Centric (31-05-2008). Consultado el 31-08-2008.
  5. ↑ Diaz MB, Krones-Herzig A, Metzger D, Ziegler A, Vegiopoulos A, Klingenspor M, Müller-Decker K, Herzig S (April 2008). «Nuclear receptor cofactor receptor interacting protein 140 controls hepatic triglyceride metabolism during wasting in mice». Hepatology 48 (3):  pp. 782–791. doi:10.1002/hep.22383. PMID 18712775. 
  6. ↑ Debevec D, Christian M, Morganstein D, Seth A, Herzog B, Parker M, White R (July 2007). «Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor alpha». Mol. Endocrinol. 21 (7):  pp. 1581–92. doi:10.1210/me.2007-0103. PMID 17456798. 
  7. ↑ Hu, Xinli; Chen Yixin, Farooqui Mariya, Thomas Mary C, Chiang Cheng-Ming, Wei Li-Na (Jan. 2004). «Suppressive effect of receptor-interacting protein 140 on coregulator binding to retinoic acid receptor complexes, histone-modifying enzyme activity, and gene activation». J. Biol. Chem. (United States) 279 (1):  pp. 319–25. doi:10.1074/jbc.M307621200. ISSN 0021-9258. PMID 14581481. 
  8. ↑ a b Farooqui, Mariya; Franco Peter J, Thompson Jim, Kagechika Hiroyuki, Chandraratna Roshantha A S, Banaszak Len, Wei Li-Na (Feb. 2003). «Effects of retinoid ligands on RIP140: molecular interaction with retinoid receptors and biological activity». Biochemistry (United States) 42 (4):  pp. 971–9. doi:10.1021/bi020497k. ISSN 0006-2960. PMID 12549917. 
  9. ↑ a b c L'Horset, F; Dauvois S, Heery D M, Cavaillès V, Parker M G (Nov. 1996). «RIP-140 interacts with multiple nuclear receptors by means of two distinct sites». Mol. Cell. Biol. (UNITED STATES) 16 (11):  pp. 6029–36. ISSN 0270-7306. PMID 8887632. 
  10. ↑ a b Zilliacus, J; Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson J A (Apr. 2001). «Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140». Mol. Endocrinol. (United States) 15 (4):  pp. 501–11. ISSN 0888-8809. PMID 11266503. 
  11. ↑ Tazawa, Hiroshi; Osman Waffa, Shoji Yutaka, Treuter Eckardt, Gustafsson Jan-Ake, Zilliacus Johanna (Jun. 2003). «Regulation of subnuclear localization is associated with a mechanism for nuclear receptor corepression by RIP140». Mol. Cell. Biol. (United States) 23 (12):  pp. 4187–98. ISSN 0270-7306. PMID 12773562. 
  12. ↑ Subramaniam, N; Treuter E, Okret S (Jun. 1999). «Receptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoids». J. Biol. Chem. (UNITED STATES) 274 (25):  pp. 18121–7. ISSN 0021-9258. PMID 10364267. 
  13. ↑ a b c Castet, Audrey; Boulahtouf Abdelhay, Versini Gwennaëlle, Bonnet Sandrine, Augereau Patrick, Vignon Françoise, Khochbin Saadi, Jalaguier Stéphan, Cavaillès Vincent (2004). «Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition». Nucleic Acids Res. (England) 32 (6):  pp. 1957–66. doi:10.1093/nar/gkh524. PMID 15060175. 
  14. ↑ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). «Towards a proteome-scale map of the human protein-protein interaction network». Nature (England) 437 (7062):  pp. 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  15. ↑ Thénot, S; Henriquet C, Rochefort H, Cavaillès V (May. 1997). «Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1». J. Biol. Chem. (UNITED STATES) 272 (18):  pp. 12062–8. ISSN 0021-9258. PMID 9115274. 
  16. ↑ Kumar, M B; Tarpey R W, Perdew G H (Aug. 1999). «Differential recruitment of coactivator RIP140 by Ah and estrogen receptors. Absence of a role for LXXLL motifs». J. Biol. Chem. (UNITED STATES) 274 (32):  pp. 22155–64. ISSN 0021-9258. PMID 10428779. 
  17. ↑ Mellgren, Gunnar; Børud Bente, Hoang Tuyen, Yri Olav Erich, Fladeby Cathrine, Lien Ernst Asbjørn, Lund Johan (May. 2003). «Characterization of receptor-interacting protein RIP140 in the regulation of SF-1 responsive target genes». Mol. Cell. Endocrinol. (Ireland) 203 (1-2):  pp. 91–103. ISSN 0303-7207. PMID 12782406. 
  18. ↑ a b Sugawara, T; Abe S, Sakuragi N, Fujimoto Y, Nomura E, Fujieda K, Saito M, Fujimoto S (Aug. 2001). «RIP 140 modulates transcription of the steroidogenic acute regulatory protein gene through interactions with both SF-1 and DAX-1». Endocrinology (United States) 142 (8):  pp. 3570–7. ISSN 0013-7227. PMID 11459805. 
  19. ↑ Perissi, Valentina; Scafoglio Claudio, Zhang Jie, Ohgi Kenneth A, Rose David W, Glass Christopher K, Rosenfeld Michael G (Mar. 2008). «TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints». Mol. Cell (United States) 29 (6):  pp. 755–66. doi:10.1016/j.molcel.2008.01.020. PMID 18374649. 

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