TRIB3

TRIB3
Homólogo 3 de Tribbles
HUGO 16228
Símbolo TRIB3
Símbolos alt. TRB3, C20orf97, NIPK, SINK, SKIP3
Datos genéticos
Locus Cr. 20 p13
Bases de datos
Entrez 57761
OMIM 607898
RefSeq NP_066981
UniProt Q96RU7

El homólogo 3 de Tribbles (TRIB3) es una proteína codificada por el gen trib3.[1] [2] [3]

TRIB3 es una posible proteína quinasa inducida por la transcripción del factor NF-KB. Esta proteína es un regulador negativo de NF-KB y puede también sensibilizar a las células para sufrir apoptosis inducida por TNF y TRAIL. Además, esta proteína puede regular negativamente a la quinasa AKT1 implicada en la supervivencia de la célula.

Interacciones

La proteína TRIB3 ha demostrado ser capaz de interaccionar con:

Referencias

  1. ↑ a b Du K, Herzig S, Kulkarni RN, Montminy M (Jun 2003). «TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver». Science 300 (5625):  pp. 1574–7. doi:10.1126/science.1079817. PMID 12791994. 
  2. ↑ Hegedus Z, Czibula A, Kiss-Toth E (Aug 2006). «Tribbles: novel regulators of cell function; evolutionary aspects». Cell Mol Life Sci 63 (14):  pp. 1632–41. doi:10.1007/s00018-006-6007-9. PMID 16715410. 
  3. ↑ «Entrez Gene: TRIB3 tribbles homolog 3 (Drosophila)».
  4. ↑ a b c d e f g h Zhou, Ying; Li Lu, Liu Qiongming, Xing Guichun, Kuai Xuezhang, Sun Jing, Yin Xiushan, Wang Jian, Zhang Lingqiang, He Fuchu (May. 2008). «E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3». Cell. Signal. (England) 20 (5):  pp. 942–8. doi:10.1016/j.cellsig.2008.01.010. ISSN 0898-6568. PMID 18276110. 
  5. ↑ Wu, Min; Xu Liang-Guo, Zhai Zhonghe, Shu Hong-Bing (Jul. 2003). «SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription». J. Biol. Chem. (United States) 278 (29):  pp. 27072–9. doi:10.1074/jbc.M209814200. ISSN 0021-9258. PMID 12736262. 
  6. ↑ Bowers, Alex J; Scully Sheila, Boylan John F (May. 2003). «SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia». Oncogene (England) 22 (18):  pp. 2823–35. doi:10.1038/sj.onc.1206367. ISSN 0950-9232. PMID 12743605. 

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