PCNA

PCNA
Antígeno nuclear de proliferación celular
HUGO 8729
Símbolo PCNA
Datos genéticos
Locus Cr. 20 p12-ter
Bases de datos
Entrez 5111
OMIM 176740
RefSeq NM_002592
UniProt P12004

El antígeno nuclear de células en proliferación (PCNA) es una proteína nuclear sintetizada en la fase G1 temprana y en la fase S del ciclo celular. Esta proteína se localiza en el núcleo y favorece la síntesis de ADN, ya que es un cofactor de la ADN polimerasa delta. Cuando existen daños en el ADN, la proteína PCNA se reubica y participa en la vía de reparación del ADN dependiente de RAD6.

Referencias

  • Matsumoto K, Moriuchi T, Koji T, Nakane PK (1987). Molecular cloning of cDNA coding for rat proliferating cell nuclear antigen (PCNA)/cyclin. EMBO J. 6 (3): 637–42. PMID 2884104.
  • Zhang G, Gibbs E, Kelman Z, O'Donnell M, Hurwitz J (1999). Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen. Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1869–74. PMID 10051561.

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  • PCNA — Proliferating Cell Nuclear Antigen, commonly known as PCNA, is a protein that acts as a processivity factor for DNA polymerase delta in eukaryotic cells. It achieves this processivity by encircling the DNA, thus creating a topological link to the …   Wikipedia

  • PCNA — Proliferating Cell Nuclear Antigen structure 3D du PCNA Le PCNA (Proliferating Cell Nuclear Antigen) est une protéine connue pour améliorer la processivité des ADN polymérases chez les eucaryotes et les Archaea lors de la réplication de l ADN …   Wikipédia en Français

  • PCNA — (= proliferating cell nuclear antigen) Commonly used marker for proliferating cells, a 35 kD protein that associates as a trimer, and as a trimer interacts with DNA polymerases d and e ; acts as an auxiliary factor for DNA repair and replication …   Dictionary of molecular biology

  • PCNA (protéine) — Structure tridimensionnelle du PCNA Le PCNA (proliferating cell nuclear antigen) est une protéine connue pour améliorer la processivité des ADN polymérases chez les eucaryotes et les Archaea lors de la réplication de l ADN[1 …   Wikipédia en Français

  • PCNA — Proliferating Cell Nuclear Antigen (Medical » Laboratory) * Publishing Company of America, Inc. (Business » NASDAQ Symbols) …   Abbreviations dictionary

  • PCNA — proliferating cell nuclear antigen …   Medical dictionary

  • PCNA — abbr. PUBLISHING CO OF AMER INC NASDAQ …   Dictionary of abbreviations

  • PCNA — • proliferating cell nuclear antigen …   Dictionary of medical acronyms & abbreviations

  • proliferating cell nuclear antigen — (= PCNA) Commonly used marker for proliferating cells, a 35 kD protein that associates as a trimer and as a trimer interacts with DNA polymerases d and e; acts as an auxiliary factor for DNA repair and replication. Transcription of PCNA is… …   Dictionary of molecular biology

  • proliferating cell nuclear antigen — (PCNA) a 36 kD trimeric nuclear acidic protein that acts as an auxiliary factor in DNA replication and repair; its levels in the body correlate with the rates of DNA synthesis and it is commonly used as a marker for proliferating cells …   Medical dictionary

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