Los premios Primetime Emmy a la mejor actriz de reparto en una serie de comedia (Primetime Emmy Award for Outstanding Supporting Actress - Comedy Series) es uno de los galardones Primetime Emmy.

Ganadores

• 1953: Vivian Vance - I Love Lucy
• 1954: Audrey Meadows - The Honeymooners
• 1955: Nanette Fabray - Caesar's Hour
• 1956: Pat Carroll - Caesar's Hour
• 1957: Ann B. Davis - The Bob Cummings Show
• 1958: premio no entregado
• 1959: Ann B. Davis - The Bob Cummings Show
• 1960: premio no entregado
• 1961: premio no entregado
• 1962: premio no entregado
• 1963: premio no entregado
• 1964: premio no entregado
• 1965: premio no entregado
• 1966: Alice Pearce - Bewitched
• 1967: Frances Bavier - The Andy Griffith Show
• 1968: Marion Lorne - Bewitched
• 1969: premio no entregado
• 1970: Karen Valentine - Room 222
• 1971: Valerie Harper - The Mary Tyler Moore Show
• 1972: Valerie Harper - The Mary Tyler Moore Show Sally Struthers, All in the Family
• 1973: Valerie Harper - The Mary Tyler Moore Show
• 1974: Cloris Leachman, The Mary Tyler Moore Show
• 1975: Betty White, The Mary Tyler Moore Show
• 1976: Betty White, The Mary Tyler Moore Show
• 1977: Mary Kay Place, Mary Hartman, Mary Hartman
• 1978: Julie Kavner, Rhoda
• 1979: Sally Struthers, All in the Family
• 1980: Loretta Swit, MASH
• 1981: Eileen Brennan, Private Benjamin
• 1982: Loretta Swit, MASH
• 1983: Carol Kane, Taxi
• 1984: Rhea Perlman, Cheers
• 1985: Rhea Perlman, Cheers
• 1986: Rhea Perlman, Cheers
• 1987: Jackee Harry, 227
• 1988: Estelle Getty, The Golden Girls
• 1989: Rhea Perlman, Cheers
• 1990: Bebe Neuwirth, Cheers
• 1991: Bebe Neuwirth, Cheers
• 1992: Laurie Metcalf, Roseanne
• 1993: Laurie Metcalf, Roseanne
• 1994: Laurie Metcalf, Roseanne
• 1995: Christine Baranski, Cybill
• 1996: Julia Louis-Dreyfus, Seinfeld
• 1997: Kristen Johnston, 3rd Rock from the Sun
• 1998: Lisa Kudrow, Friends
• 1999: Kristen Johnston, 3rd Rock from the Sun
• 2000: Megan Mullally, Will & Grace
• 2001: Doris Roberts, Everybody Loves Raymond
• 2002: Doris Roberts, Everybody Loves Raymond
• 2003: Doris Roberts, Everybody Loves Raymond
• 2004: Cynthia Nixon, Sex and the City
• 2005: Doris Roberts, Everybody Loves Raymond
• 2006: Megan Mullally, Will and Grace
• 2007: Jaime Pressly, My Name Is Earl
• 2008: Jean Smart, Samantha Who?