AATF

AATF
Factor de transcripción antagonista de apoptosis
HUGO 19235
Símbolo AATF
Símbolos alt. CHE1; CHE-1; DED
Datos genéticos
Locus Cr. 17 q12
Bases de datos
Entrez 26574
OMIM 608463
RefSeq NP_036270
UniProt Q9NY61

El factor de transcripción antagonista de apoptosis (AATF) es una proteína codificada en humanos por el gen AATF.[1] [2] [3]

La proteína codificada por este gen fue identificada debido a su interacción con MAP3K12/DLK, una proteína quinasa implicada en la inducción de apoptosis. La proteína AATF contiene una cremallera de leucina, que es un motivo característico de los factores de transcripción, y ha demostrado poseer una elevada capacidad de transactivación cuando se encuentra fusionada al dominio de unión a ADN de Gal4. La sobre-expresión de este gen interfiere con la apoptosis inducida por MAP3K12.[3]

Interacciones

La proteína AATF ha demostrado ser capaz de interaccionar con:

Referencias

  1. Lindfors K, Halttunen T, Huotari P, Nupponen N, Vihinen M, Visakorpi T, Maki M, Kainulainen H (Oct 2000). «Identification of novel transcription factor-like gene from human intestinal cells». Biochem Biophys Res Commun 276 (2):  pp. 660–6. doi:10.1006/bbrc.2000.3480. PMID 11027528. 
  2. a b Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C (Jun 2000). «Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb». FASEB J 14 (7):  pp. 904–12. PMID 10783144. 
  3. a b «Entrez Gene: AATF apoptosis antagonizing transcription factor».
  4. Di Padova, Monica; Bruno Tiziana, De Nicola Francesca, Iezzi Simona, D'Angelo Carmen, Gallo Rita, Nicosia Daniela, Corbi Nicoletta, Biroccio Annamaria, Floridi Aristide, Passananti Claudio, Fanciulli Maurizio (Sep. 2003). «Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter». J. Biol. Chem. (United States) 278 (38):  pp. 36496–504. doi:10.1074/jbc.M306694200. ISSN 0021-9258. PMID 12847090. 
  5. Fanciulli, M; Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C (May. 2000). «Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb». FASEB J. (UNITED STATES) 14 (7):  pp. 904–12. ISSN 0892-6638. PMID 10783144. 
  6. Guo, Qing; Xie Jun (Feb. 2004). «AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4». J. Biol. Chem. (United States) 279 (6):  pp. 4596–603. doi:10.1074/jbc.M309811200. ISSN 0021-9258. PMID 14627703. 
  7. Bruno, Tiziana; De Angelis Roberta, De Nicola Francesca, Barbato Christian, Di Padova Monica, Corbi Nicoletta, Libri Valentina, Benassi Barbara, Mattei Elisabetta, Chersi Alberto, Soddu Silvia, Floridi Aristide, Passananti Claudio, Fanciulli Maurizio (Nov. 2002). «Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb». Cancer Cell (United States) 2 (5):  pp. 387–99. ISSN 1535-6108. PMID 12450794. 

Enlaces externos


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