ATF6

ATF6
ATF6
HUGO 791
Símbolo ATF6
Datos genéticos
Locus Cr. 1 q23.3
Bases de datos
Entrez 22926
OMIM 605537
RefSeq NP_031374
UniProt P18850

El factor de transcripción activador 6, también conocido como ATF6 (de sus siglas en inglés Activating Transcription Factor 6), es una proteína codificada en humanos por el gen atf6,[1] [2] [3] implicada en respuesta a la presencia de proteínas mal plegadas.

Contenido

Función

ATF6 es un factor de transcripción transmembrana del retículo endoplasmático (RE) regulado por estrés que activa la transcripción de las moléculas del RE.[4] La acumulación de proteínas mal plegadas en el RE resulta en la proteolisis de ATF6. La región citosólica de ATF6 se translocará al núcleo y actuará como un factor de transcripción que activará la expresión de chaperonas del RE.

Interacciones

La proteína ATF6 ha demostrado ser capaz de interaccionar con:

Véase también

  • Factor de transcripción activador

Referencias

  1. ↑ Hai TW, Liu F, Coukos WJ, Green MR (December 1989). «Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers». Genes Dev. 3 (12B):  pp. 2083–90. doi:10.1101/gad.3.12b.2083. PMID 2516827. 
  2. ↑ Zhu C, Johansen FE, Prywes R (September 1997). «Interaction of ATF6 and serum response factor». Mol. Cell. Biol. 17 (9):  pp. 4957–66. PMID 9271374. PMC 232347. http://mcb.asm.org/cgi/content/abstract/17/9/4957. 
  3. ↑ Meex SJ, van Greevenbroek MM, Ayoubi TA, Vlietinck R, van Vliet-Ostaptchouk JV, Hofker MH, Vermeulen VM, Schalkwijk CG, Feskens EJ, Boer JM, Stehouwer CD, van der Kallen CJ, de Bruin TW (July 2007). «Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians». J. Clin. Endocrinol. Metab. 92 (7):  pp. 2720–5. doi:10.1210/jc.2006-2280. PMID 17440018. 
  4. ↑ «Entrez Gene: ATF6 activating transcription factor 6».
  5. ↑ Li, M; Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee A S (Jul. 2000). «ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1». Mol. Cell. Biol. (UNITED STATES) 20 (14):  pp. 5096–106. ISSN 0270-7306. PMID 10866666. 
  6. ↑ Zhu, C; Johansen F E, Prywes R (Sep. 1997). «Interaction of ATF6 and serum response factor». Mol. Cell. Biol. (UNITED STATES) 17 (9):  pp. 4957–66. ISSN 0270-7306. PMID 9271374. 

Enlaces externos


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