Cofactor de BRCA1

Cofactor de BRCA1
Cofactor de BRCA1
Símbolo COBRA1
Símbolos alt. DKFZP586B0519, NELF-B, NELFB
Datos genéticos
Locus Cr. 9 q34.3
Bases de datos
Entrez 25920
RefSeq XP_001133009
UniProt Q8WX92

El cofactor de BRCA1, también conocido como COBRA1, es un gen humano[1] que codifica la proteína NELF-B. NELF-B es una de las subunidades del factor de elongación negativo (NELF), que también incluye NELF-A (WHSC2; MIM 606026), NELF-C o NELF-D (TH1L; MIM 605297) y NELF-E (RDBP; MIM 154040). NELF actúa junto con el factor de inducción de sensibilidad a DRB (DSIF), un heterodímero de SPT4 (SUPT4H1; MIM 603555) y SPT5 (SUPT5H; MIM 602102), para dar lugar a una pausa transcripcional de la ARN polimerasa II (véase MIM 180660).[2] [3] COBRA1 fue identificado inicialmente en experimento de doble híbrido en levadura utilizando el dominio BRCT1 de la proteína BRCA1 como cebo.[4]

Interacciones

El cofactor de BRCA1 ha demostrado ser capaz de interaccionar con:

Referencias

  1. ↑ «Entrez Gene: COBRA1 cofactor of BRCA1».
  2. ↑ Narita, Takashi; Yamaguchi, Yuki ; Yano, Keiichi; Sugimoto, Seiji; Chanarat, Sittinan; Wada, Tadashi; Kim, Dong-ki; Hasegawa, Jun; Omori, Masashi; Inukai, Naoto; Endoh, Masaki; Yamada, Tomoko; Handa, Hiroshi (2003). «Human Transcription Elongation Factor NELF: Identification of Novel Subunits and Reconstitution of the Functionally Active Complex». Molecular and Cellular Biology 23:  pp. 1863–1873. doi:10.1128/MCB.23.6.1863-1873.2003. PMID 12612062. 
  3. ↑ Yamaguchi Y, Takagi T, Wada T, Yano K, Furuya A, Sugimoto S, Hasegawa J, Handa H (Apr. 1999). «NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation». Cell (United States) 97 (1):  pp. 41–51. PMID 10199401. 
  4. ↑ Ye, Q.; Hu, Y.F.; Zhong, H.; Nye, A.C.; Belmont, A.S.; Li, R. (2001). «BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations». The Journal of Cell Biology 155 (6):  pp. 911–922. doi:10.1083/jcb.200108049. 
  5. ↑ Aiyar, Sarah E; Sun Jian-long, Blair Ashley L, Moskaluk Christopher A, Lu Yun-zhe, Ye Qi-Nong, Yamaguchi Yuki, Mukherjee Amitava, Ren Da-ming, Handa Hiroshi, Li Rong (Sep. 2004). «Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor». Genes Dev. (United States) 18 (17):  pp. 2134–46. doi:10.1101/gad.1214104. ISSN 0890-9369. PMID 15342491. 
  6. ↑ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). «Large-scale mapping of human protein-protein interactions by mass spectrometry». Mol. Syst. Biol. (England) 3:  pp. 89. doi:10.1038/msb4100134. PMID 17353931. 
  7. ↑ a b Narita, Takashi; Yamaguchi Yuki, Yano Keiichi, Sugimoto Seiji, Chanarat Sittinan, Wada Tadashi, Kim Dong-ki, Hasegawa Jun, Omori Masashi, Inukai Naoto, Endoh Masaki, Yamada Tomoko, Handa Hiroshi (Mar. 2003). «Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex». Mol. Cell. Biol. (United States) 23 (6):  pp. 1863–73. ISSN 0270-7306. PMID 12612062. 
  8. ↑ Lehner, Ben; Semple Jennifer I, Brown Stephanie E, Counsell Damian, Campbell R Duncan, Sanderson Christopher M (Jan. 2004). «Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region». Genomics (United States) 83 (1):  pp. 153–67. ISSN 0888-7543. PMID 14667819. 
  9. ↑ a b Zhong, Hongjun; Zhu Jianhua, Zhang Hao, Ding Lihua, Sun Yan, Huang Cuifen, Ye Qinong (Dec. 2004). «COBRA1 inhibits AP-1 transcriptional activity in transfected cells». Biochem. Biophys. Res. Commun. (United States) 325 (2):  pp. 568–73. doi:10.1016/j.bbrc.2004.10.079. ISSN 0006-291X. PMID 15530430. 
  10. ↑ Ye, Q; Hu Y F, Zhong H, Nye A C, Belmont A S, Li R (Dec. 2001). «BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations». J. Cell Biol. (United States) 155 (6):  pp. 911–21. doi:10.1083/jcb.200108049. ISSN 0021-9525. PMID 11739404. 

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