CD29

CD29
Integrina beta 1
HUGO 6153
Símbolo ITGB1
Símbolos alt. CD29; FNRB; GPIIA; MDF2; MSK12; VLAB
Datos genéticos
Locus Cr. 10 p11.22
Bases de datos
Entrez 3688
OMIM 135630
RefSeq NP_002202
UniProt P05556

La integrina beta 1 (ITGB1 ó CD29) es una proteína codificada en humanos por el gen ITGB1.[1] CD29 es una integrina asociada con numerosos receptores de antígenos. Se conoce su asociación con CD49c para formar el complejo α3β1, que reacciona con moléculas como NTN1 y reelina.

Las integrinas son proteínas heterodiméricas formadas por subunidades alfa y beta. Se han descrito al menos 18 subunidades alfa y 8 beta en mamíferos. Los miembros de la familia de las integrinas son receptores de membrana implicados en adhesión celular y reconocimiento de señales en diversos procesos como la embriogénesis, la hemostasis, la reparación tisular, la respuesta inmune y la difusión metastásica de células tumorales. CD29 se corresponde con una subunidad beta. Se han descrito seis variantes transcripcionales de este gen, que codifican cinco isoformas de la proteína con extremos C-terminales alternados.[2]

Interacciones

La integrina beta 1 ha demostrado ser capaz de interaccionar con:

Referencias

  1. ↑ Goodfellow PJ, Nevanlinna HA, Gorman P, Sheer D, Lam G, Goodfellow PN (Jul 1989). «Assignment of the gene encoding the beta-subunit of the human fibronectin receptor (beta-FNR) to chromosome 10p11.2». Ann Hum Genet 53 (Pt 1):  pp. 15–22. PMID 2524991. 
  2. ↑ «Entrez Gene: ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)».
  3. ↑ Tachibana, I; Bodorova J, Berditchevski F, Zutter M M, Hemler M E (Nov. 1997). «NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins». J. Biol. Chem. (UNITED STATES) 272 (46):  pp. 29181–9. ISSN 0021-9258. PMID 9360996. 
  4. ↑ Radford, K J; Thorne R F, Hersey P (May. 1996). «CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma». Biochem. Biophys. Res. Commun. (UNITED STATES) 222 (1):  pp. 13–8. doi:10.1006/bbrc.1996.0690. ISSN 0006-291X. PMID 8630057. 
  5. ↑ a b Mazzocca, Antonio; Carloni Vinicio, Sciammetta Silvia, Cordella Claudia, Pantaleo Pietro, Caldini Anna, Gentilini Paolo, Pinzani Massimo (Sep. 2002). «Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration». J. Hepatol. (England) 37 (3):  pp. 322–30. ISSN 0168-8278. PMID 12175627. 
  6. ↑ a b van der Flier, Arjan; Kuikman Ingrid, Kramer Duco, Geerts Dirk, Kreft Maaike, Takafuta Toshiro, Shapiro Sandor S, Sonnenberg Arnoud (Jan. 2002). «Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits». J. Cell Biol. (United States) 156 (2):  pp. 361–76. doi:10.1083/jcb.200103037. ISSN 0021-9525. PMID 11807098. 
  7. ↑ Loo, D T; Kanner S B, Aruffo A (Sep. 1998). «Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction». J. Biol. Chem. (UNITED STATES) 273 (36):  pp. 23304–12. ISSN 0021-9258. PMID 9722563. 
  8. ↑ Serru, V; Le Naour F, Billard M, Azorsa D O, Lanza F, Boucheix C, Rubinstein E (May. 1999). «Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions». Biochem. J. (ENGLAND) 340 ( Pt 1):  pp. 103–11. ISSN 0264-6021. PMID 10229664. 
  9. ↑ Lozahic, S; Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E (Mar. 2000). «CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans». Eur. J. Immunol. (GERMANY) 30 (3):  pp. 900–7. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. ISSN 0014-2980. PMID 10741407. 
  10. ↑ Poinat, Patrice; De Arcangelis Adèle, Sookhareea Satis, Zhu Xiaoping, Hedgecock Edward M, Labouesse Michel, Georges-Labouesse Elisabeth (Apr. 2002). «A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans». Curr. Biol. (England) 12 (8):  pp. 622–31. ISSN 0960-9822. PMID 11967148. 
  11. ↑ Wixler, V; Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M (Oct. 2000). «The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes». J. Biol. Chem. (UNITED STATES) 275 (43):  pp. 33669–78. doi:10.1074/jbc.M002519200. ISSN 0021-9258. PMID 10906324. 
  12. ↑ Fournier, Henri-Noël; Dupé-Manet Sandra, Bouvard Daniel, Lacombe Marie-Lise, Marie Christiane, Block Marc R, Albiges-Rizo Corinne (Jun. 2002). «Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement». J. Biol. Chem. (United States) 277 (23):  pp. 20895–902. doi:10.1074/jbc.M200200200. ISSN 0021-9258. PMID 11919189. 
  13. ↑ a b Lee, H-S; Millward-Sadler S J, Wright M O, Nuki G, Al-Jamal R, Salter D M (Nov. 2002). «Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction». Osteoarthr. Cartil. (England) 10 (11):  pp. 890–7. ISSN 1063-4584. PMID 12435334. 
  14. ↑ Parsons, Maddy; Keppler Melanie D, Kline Adam, Messent Anthea, Humphries Martin J, Gilchrist Ruth, Hart Ian R, Quittau-Prevostel Corinne, Hughes William E, Parker Peter J, Ng Tony (Aug. 2002). «Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis». Mol. Cell. Biol. (United States) 22 (16):  pp. 5897–911. ISSN 0270-7306. PMID 12138200. 
  15. ↑ Han, D C; Rodriguez L G, Guan J L (Jan. 2001). «Identification of a novel interaction between integrin beta1 and 14-3-3beta». Oncogene (England) 20 (3):  pp. 346–57. doi:10.1038/sj.onc.1204068. ISSN 0950-9232. PMID 11313964. 
  16. ↑ Chang, D D; Wong C, Smith H, Liu J (Sep. 1997). «ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin». J. Cell Biol. (UNITED STATES) 138 (5):  pp. 1149–57. ISSN 0021-9525. PMID 9281591. 
  17. ↑ Chang, David D; Hoang Bao Q, Liu Jenny, Springer Timothy A (Mar. 2002). «Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin». J. Biol. Chem. (United States) 277 (10):  pp. 8140–5. doi:10.1074/jbc.M109031200. ISSN 0021-9258. PMID 11741908. 
  18. ↑ Hadari, Y R; Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (Jul. 2000). «Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis». J. Cell. Sci. (ENGLAND) 113 ( Pt 13):  pp. 2385–97. ISSN 0021-9533. PMID 10852818. 
  19. ↑ Liliental, J; Chang D D (Jan. 1998). «Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit». J. Biol. Chem. (UNITED STATES) 273 (4):  pp. 2379–83. ISSN 0021-9258. PMID 9442085. 

Enlaces externos


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