MAP2K2

MAP2K2
MAP quinasa quinasa específica dual 2
Protein MAP2K2 PDB 1s9i.png
Estructura tridimensional de la proteína MAP2K2.
HUGO 6842
Símbolo MAP2K2
Símbolos alt. MAPKK2, MEK2, MKK2, PRKMK2
Datos genéticos
Locus Cr. 19 p13.3
Bases de datos
Entrez 5605
OMIM 601263
PDB 1s9i
RefSeq NP_109587
UniProt P36507

La MAP quinasa quinasa específica dual 2 (MAP2K2) es una enzima codificada en humanos por el gen MAP2K2.[1]

Esta quinasa es una proteína quinasa específica dual, que pertenece a la familia de las MAP quinasa quinasas. MAP2K2 es conocida por jugar un papel crucial en la transducción de señales de factores de crecimiento mitógenos. Es capaz de fosforilar y activar a los complejos MAPK1/ERK2 y MAPK2/ERK3. La activación de esta quinasa es dependiente de fosforilación de Ser/Thr por MAP quinasa quinasa quinasas. La inhibición o degradación de esta quinasa parece estar implicada en la patogénesis de Yersinia y del ántrax.[2]

Interacciones

La proteína MAP2K2 ha demostrado ser capaz de interaccionar con:

Referencias

  1. Zheng CF, Guan KL (Jun 1993). «Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2». J Biol Chem 268 (15):  pp. 11435–9. PMID 8388392. 
  2. «Entrez Gene: MAP2K2 mitogen-activated protein kinase kinase 2».
  3. Marti, A; Luo Z, Cunningham C, Ohta Y, Hartwig J, Stossel T P, Kyriakis J M, Avruch J (Jan. 1997). «Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells». J. Biol. Chem. (UNITED STATES) 272 (5):  pp. 2620–8. ISSN 0021-9258. PMID 9006895. 
  4. Butch, E R; Guan K L (Feb. 1996). «Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2». J. Biol. Chem. (UNITED STATES) 271 (8):  pp. 4230–5. ISSN 0021-9258. PMID 8626767. 
  5. Zheng, C F; Guan K L (Nov. 1993). «Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases». J. Biol. Chem. (UNITED STATES) 268 (32):  pp. 23933–9. ISSN 0021-9258. PMID 8226933. 
  6. Yin, Xiang L; Chen She, Yan Jun, Hu Yun, Gu Jian X (Feb. 2002). «Identification of interaction between MEK2 and A-Raf-1». Biochim. Biophys. Acta (Netherlands) 1589 (1):  pp. 71–6. ISSN 0006-3002. PMID 11909642. 

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