MAP2K6

MAP2K6
MAP quinasa quinasa específica dual 6
HUGO 6846
Símbolo MAP2K6
Símbolos alt. MAPKK6, MEK6, MKK6, PRKMK6, SAPKK3
Datos genéticos
Locus Cr. 17 q24.3
Bases de datos
Entrez 5608
OMIM 601254
RefSeq NP_002749
UniProt P52564

La MAP quinasa quinasa específica dual 6 (MAP2K6) es una enzima codificada en humanos por el gen MAP2K6.[1]

Esta quinasa pertenece a la familia de las proteínas quinasas específicas duales, que actúan como MAP quinasa quinasas. Las MAP quinasas, también conocidas como quinasas reguladas por señales extracelulares (ERKs), actúan como punto de integración de multitud de señales bioquímicas. MAP2K6 fosforila y activa a la MAPK p38 en respuesta a citoquinas proinflamatorias o a estrés ambiental. Como componente esencial de la ruta de transducción de señales mediada por p38, esta quinasa se encuentra implicada en multitud de procesos celulares como la parada del ciclo celular inducida por estrés, la activación de la transcripción y la apoptosis.[2]

Interacciones

La proteína MAP2K6 ha demostrado ser capaz de interaccionar con:

Referencias

  1. ↑ Han J, Lee JD, Jiang Y, Li Z, Feng L, Ulevitch RJ (Jun 1996). «Characterization of the structure and function of a novel MAP kinase kinase (MKK6)». J Biol Chem 271 (6):  pp. 2886–91. PMID 8621675. 
  2. ↑ «Entrez Gene: MAP2K6 mitogen-activated protein kinase kinase 6».
  3. ↑ a b Chen, Z; Cobb M H (May. 2001). «Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2». J. Biol. Chem. (United States) 276 (19):  pp. 16070–5. doi:10.1074/jbc.M100681200. ISSN 0021-9258. PMID 11279118. 
  4. ↑ Huang, Shile; Shu Lili, Dilling Michael B, Easton John, Harwood Franklin C, Ichijo Hidenori, Houghton Peter J (Jun. 2003). «Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)». Mol. Cell (United States) 11 (6):  pp. 1491–501. ISSN 1097-2765. PMID 12820963. 
  5. ↑ Morita, K; Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, Ichijo H (Nov. 2001). «Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress». EMBO J. (England) 20 (21):  pp. 6028–36. doi:10.1093/emboj/20.21.6028. ISSN 0261-4189. PMID 11689443. 
  6. ↑ Sanz-Moreno, Victoria; Casar Berta, Crespo Piero (May. 2003). «p38alpha isoform Mxi2 binds to extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase and regulates its nuclear activity by sustaining its phosphorylation levels». Mol. Cell. Biol. (United States) 23 (9):  pp. 3079–90. ISSN 0270-7306. PMID 12697810. 
  7. ↑ Raingeaud, J; Whitmarsh A J, Barrett T, Dérijard B, Davis R J (Mar. 1996). «MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway». Mol. Cell. Biol. (UNITED STATES) 16 (3):  pp. 1247–55. ISSN 0270-7306. PMID 8622669. 
  8. ↑ Stein, B; Brady H, Yang M X, Young D B, Barbosa M S (May. 1996). «Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade». J. Biol. Chem. (UNITED STATES) 271 (19):  pp. 11427–33. ISSN 0021-9258. PMID 8626699. 
  9. ↑ Ishitani, Tohru; Takaesu Giichi, Ninomiya-Tsuji Jun, Shibuya Hiroshi, Gaynor Richard B, Matsumoto Kunihiro (Dec. 2003). «Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling». EMBO J. (England) 22 (23):  pp. 6277–88. doi:10.1093/emboj/cdg605. ISSN 0261-4189. PMID 14633987. 
  10. ↑ Wang, C; Deng L, Hong M, Akkaraju G R, Inoue J, Chen Z J (Jul. 2001). «TAK1 is a ubiquitin-dependent kinase of MKK and IKK». Nature (England) 412 (6844):  pp. 346–51. doi:10.1038/35085597. ISSN 0028-0836. PMID 11460144. 
  11. ↑ Ninomiya-Tsuji, J; Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K (Mar. 1999). «The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway». Nature (ENGLAND) 398 (6724):  pp. 252–6. doi:10.1038/18465. ISSN 0028-0836. PMID 10094049. 
  12. ↑ Sakurai, H; Miyoshi H, Mizukami J, Sugita T (Jun. 2000). «Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1». FEBS Lett. (NETHERLANDS) 474 (2-3):  pp. 141–5. ISSN 0014-5793. PMID 10838074. 

Wikimedia foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Mira otros diccionarios:

  • MAP2K6 — Main article: Mitogen activated protein kinase kinase Mitogen activated protein kinase kinase 6 Rendering based on PDB 3 …   Wikipedia

  • Mitogen-activated protein kinase kinase — For other uses, see MKK (disambiguation). Mitogen activated protein kinase kinase [sic] (also known as MAP2K) is a kinase enzyme which phosphorylates mitogen activated protein kinase (MAPK). MAP2K is classified as EC 2.7.12.2. There are seven… …   Wikipedia

  • Mitogen-activated protein kinase — Identifiers EC number 2.7.11.24 CAS number 142243 02 5 …   Wikipedia

  • MAP kinase kinase kinase — (or MAP3K or MEKK) is a serine/threonine specific protein kinase which acts upon MAP kinase kinase. In humans there are at least 19 genes: MAP3K1 (aka MEKK1) MAP3K2 MAP3K3 (aka MEKK3) MAP3K4 MAP3K5 (aka ASK1) MAP3K6 (aka ASK2) MAP3K7 (aka MEKK7)… …   Wikipedia

  • MAP3K7 — Митоген активируемая киназа киназы протеинкиназы 7 Обозначения …   Википедия

  • MAP kinase kinase kinase kinase — Mitogen activated protein kinase kinase kinase kinase (MAP4K) is a family of proteins involved in cellular signal transduction. This list is incomplete; you can help by expanding it. MAP4K1 (aka HPK1) MAP4K2 (aka GCK) MAP4K3 MAP4K4 MAP4K5… …   Wikipedia

  • ASK1 — Mitogen activated protein kinase kinase kinase 5 PDB rendering based on 2clq …   Wikipedia

  • Protein kinase A — In cell biology, Protein kinase A (PKA) refers to a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP dependent protein kinase (EC 2.7.11.11). Protein kinase A has several functions… …   Wikipedia

  • Cyclin-dependent kinase — Schematic of the cell cycle. outer ring: I=Interphase, M=Mitosis; inner ring: M=Mitosis; G1=Gap phase 1; S=Synthesis; G2=Gap phase 2. The duration of mitosis in relation to the other phases has been exaggerated in this diagram Cyclin dependent… …   Wikipedia

  • Hypertrichosis — Classification and external resources Stephan Bibrowski, also known as Lionel the Lion Faced Man, had congenital terminal hypertrichosis. ICD …   Wikipedia

Compartir el artículo y extractos

Link directo
… Do a right-click on the link above
and select “Copy Link”