MAP2K6

MAP2K6
MAP quinasa quinasa específica dual 6
HUGO 6846
Símbolo MAP2K6
Símbolos alt. MAPKK6, MEK6, MKK6, PRKMK6, SAPKK3
Datos genéticos
Locus Cr. 17 q24.3
Bases de datos
Entrez 5608
OMIM 601254
RefSeq NP_002749
UniProt P52564

La MAP quinasa quinasa específica dual 6 (MAP2K6) es una enzima codificada en humanos por el gen MAP2K6.[1]

Esta quinasa pertenece a la familia de las proteínas quinasas específicas duales, que actúan como MAP quinasa quinasas. Las MAP quinasas, también conocidas como quinasas reguladas por señales extracelulares (ERKs), actúan como punto de integración de multitud de señales bioquímicas. MAP2K6 fosforila y activa a la MAPK p38 en respuesta a citoquinas proinflamatorias o a estrés ambiental. Como componente esencial de la ruta de transducción de señales mediada por p38, esta quinasa se encuentra implicada en multitud de procesos celulares como la parada del ciclo celular inducida por estrés, la activación de la transcripción y la apoptosis.[2]

Interacciones

La proteína MAP2K6 ha demostrado ser capaz de interaccionar con:

Referencias

  1. ↑ Han J, Lee JD, Jiang Y, Li Z, Feng L, Ulevitch RJ (Jun 1996). «Characterization of the structure and function of a novel MAP kinase kinase (MKK6)». J Biol Chem 271 (6):  pp. 2886–91. PMID 8621675. 
  2. ↑ «Entrez Gene: MAP2K6 mitogen-activated protein kinase kinase 6».
  3. ↑ a b Chen, Z; Cobb M H (May. 2001). «Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2». J. Biol. Chem. (United States) 276 (19):  pp. 16070–5. doi:10.1074/jbc.M100681200. ISSN 0021-9258. PMID 11279118. 
  4. ↑ Huang, Shile; Shu Lili, Dilling Michael B, Easton John, Harwood Franklin C, Ichijo Hidenori, Houghton Peter J (Jun. 2003). «Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)». Mol. Cell (United States) 11 (6):  pp. 1491–501. ISSN 1097-2765. PMID 12820963. 
  5. ↑ Morita, K; Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, Ichijo H (Nov. 2001). «Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress». EMBO J. (England) 20 (21):  pp. 6028–36. doi:10.1093/emboj/20.21.6028. ISSN 0261-4189. PMID 11689443. 
  6. ↑ Sanz-Moreno, Victoria; Casar Berta, Crespo Piero (May. 2003). «p38alpha isoform Mxi2 binds to extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase and regulates its nuclear activity by sustaining its phosphorylation levels». Mol. Cell. Biol. (United States) 23 (9):  pp. 3079–90. ISSN 0270-7306. PMID 12697810. 
  7. ↑ Raingeaud, J; Whitmarsh A J, Barrett T, Dérijard B, Davis R J (Mar. 1996). «MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway». Mol. Cell. Biol. (UNITED STATES) 16 (3):  pp. 1247–55. ISSN 0270-7306. PMID 8622669. 
  8. ↑ Stein, B; Brady H, Yang M X, Young D B, Barbosa M S (May. 1996). «Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade». J. Biol. Chem. (UNITED STATES) 271 (19):  pp. 11427–33. ISSN 0021-9258. PMID 8626699. 
  9. ↑ Ishitani, Tohru; Takaesu Giichi, Ninomiya-Tsuji Jun, Shibuya Hiroshi, Gaynor Richard B, Matsumoto Kunihiro (Dec. 2003). «Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling». EMBO J. (England) 22 (23):  pp. 6277–88. doi:10.1093/emboj/cdg605. ISSN 0261-4189. PMID 14633987. 
  10. ↑ Wang, C; Deng L, Hong M, Akkaraju G R, Inoue J, Chen Z J (Jul. 2001). «TAK1 is a ubiquitin-dependent kinase of MKK and IKK». Nature (England) 412 (6844):  pp. 346–51. doi:10.1038/35085597. ISSN 0028-0836. PMID 11460144. 
  11. ↑ Ninomiya-Tsuji, J; Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K (Mar. 1999). «The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway». Nature (ENGLAND) 398 (6724):  pp. 252–6. doi:10.1038/18465. ISSN 0028-0836. PMID 10094049. 
  12. ↑ Sakurai, H; Miyoshi H, Mizukami J, Sugita T (Jun. 2000). «Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1». FEBS Lett. (NETHERLANDS) 474 (2-3):  pp. 141–5. ISSN 0014-5793. PMID 10838074. 

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