MED16

MED16
Receptor de hormona tiroidea asociado a la proteína 5
HUGO 11796
Símbolo THRAP5
Símbolos alt. DRIP92, MED16, TRAP95
Datos genéticos
Locus Cr. 19 p13.3-17q12
Bases de datos
Entrez 10025
OMIM 604062
RefSeq XP_001130102
UniProt Q9Y2X0

La proteína mediadora de la transcripción de la subunidad 16 de la ARN polimerasa (MED16) es una enzima que, en humanos, es codificada por el gen med16.[1] [2] [3] La proteína MED16 está implicada en la regulación de la expresión de la subunidad 16S de la ARN polimerasa.

Interacciones

La proteína MED16 ha demostrado ser capaz de interaccionar con:

  • Receptor de hormona tiroidea alfa[2]
  • Receptor de estrógeno alfa[4]
  • Cdk8[2] [4]

Referencias

  1. Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Naar AM, Erdjument-Bromage H, Tempst P, Freedman LP (Jun 1999). «Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex». Nature 398 (6730):  pp. 824–8. doi:10.1038/19783. PMID 10235266. 
  2. a b c Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Apr 1999). «Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators». Mol Cell 3 (3):  pp. 361–70. PMID 10198638. 
  3. «Entrez Gene: THRAP5 thyroid hormone receptor associated protein 5».
  4. a b Kang, Yun Kyoung; Guermah Mohamed, Yuan Chao-Xing, Roeder Robert G (Mar. 2002). «The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro». Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (5):  pp. 2642–7. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMID 11867769. 

Enlaces externos


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Mira otros diccionarios:

  • MED16 — Thyroid hormone receptor associated protein 5, also known as THRAP5, is a human gene.cite web | title = Entrez Gene: THRAP5 thyroid hormone receptor associated protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • Estrogen receptor alpha — Estrogen receptor 1 PDB rendering based on 1a52 …   Wikipedia

  • Mediator (coactivator) — Mediator is a multiprotein complex that functions as a transcriptional coactivator. It was discovered by Roger D. Kornberg, winner of the 2006 Nobel Prize in Chemistry. It is also referred to in scientific literature as the Vitamin D Receptor… …   Wikipedia

  • Thyroid hormone receptor alpha — Thyroid hormone receptor, alpha PDB rendering based on 1nav …   Wikipedia

  • Cyclin-dependent kinase 8 — Identifiers Symbols CDK8; K35; MGC126074; MGC126075 External IDs …   Wikipedia

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