- PIK3R3
-
Subunidad reguladora gamma de la fosfatidilinositol 3-quinasa 
Estructura tridimensional de la proteína PIK3R3.HUGO 8981 Símbolo PIK3R3 Símbolos alt. DKFZp686P05226; FLJ41892; p55-GAMMA Datos genéticos Locus Cr. 1 p34.1 Bases de datos Entrez 8503 OMIM 606076 PDB 2pna RefSeq NP_003620 UniProt Q92569 La subunidad reguladora gamma de la fosfatidilinositol 3-quinasa (PIK3R3) es una enzima codificada en humanos por el gen PIK3R3.[1] [2]
Interacciones
La proteína PIK3R3 ha demostrado ser capaz de interaccionar con:
- IGF1R[3]
- IRS1[4] [3]
- Proteína del retinoblastoma[5]
Referencias
- ↑ Dey BR, Furlanetto RW, Nissley SP (May 1998). «Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor». Gene 209 (1-2): pp. 175–83. PMID 9524259.
- ↑ «Entrez Gene: PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)».
- ↑ a b Mothe, I; Delahaye L, Filloux C, Pons S, White M F, Van Obberghen E (Dec. 1997). «Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins». Mol. Endocrinol. (UNITED STATES) 11 (13): pp. 1911–23. ISSN 0888-8809. PMID 9415396.
- ↑ Xia, X; Serrero G (Aug. 1999). «Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation». Biochem. J. (ENGLAND) 341 ( Pt 3): pp. 831–7. ISSN 0264-6021. PMID 10417350.
- ↑ Xia, Xianmin; Cheng Aiwu, Akinmade Damilola, Hamburger Anne W (Mar. 2003). «The N-terminal 24 amino acids of the p55 gamma regulatory subunit of phosphoinositide 3-kinase binds Rb and induces cell cycle arrest». Mol. Cell. Biol. (United States) 23 (5): pp. 1717–25. ISSN 0270-7306. PMID 12588990.
Categorías:- Genes del cromosoma 1
- Proteínas humanas
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