PRKG1

PRKG1
Proteína quinasa dependiente del cGMP tipo I
HUGO 9414
Símbolo cGK1
Datos genéticos
Código de gen PRKG1
Tipo de gen Gen codificante
Locus Cr. 10 q11.2
Estructura/Función proteica
Tamaño 671 (aminoácidos)
Bases de datos
Número EC 2.7.11.12
Entrez 5592
OMIM 176894
RefSeq NM_001098512
UniProt Q13976

La proteína quinasa GMPc dependiente tipo I (PRKG1) (EC 2.7.11.12) es una enzima codificada en humanos por el gen PRKG1.[1] [2] [3] Pertenece a la familia de las serina/treonina proteína quinasas específicas.

Interacciones

La proteína PRKG1 ha demostrado ser capaz de interaccionar con:

Referencias

  1. Sandberg M, Natarajan V, Ronander I, Kalderon D, Walter U, Lohmann SM, Jahnsen T (Nov 1989). «Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat». FEBS Lett 255 (2):  pp. 321–9. PMID 2792381. 
  2. Orstavik S, Sandberg M, Berube D, Natarajan V, Simard J, Walter U, Gagne R, Hansson V, Jahnsen T (Apr 1992). «Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10». Cytogenet Cell Genet 59 (4):  pp. 270–3. PMID 1544322. 
  3. «Entrez Gene: PRKG1 protein kinase, cGMP-dependent, type I».
  4. a b Schlossmann, J; Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang G X, Allescher H D, Korth M, Wilm M, Hofmann F, Ruth P (Mar. 2000). «Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta». Nature (ENGLAND) 404 (6774):  pp. 197–201. doi:10.1038/35004606. ISSN 0028-0836. PMID 10724174. 
  5. Tang, K Mary; Wang Guang-rong, Lu Ping, Karas Richard H, Aronovitz Mark, Heximer Scott P, Kaltenbronn Kevin M, Blumer Kendall J, Siderovski David P, Zhu Yan, Mendelsohn Michael E, Tang Mary, Wang Guang (Dec. 2003). «Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure». Nat. Med. (United States) 9 (12):  pp. 1506–12. doi:10.1038/nm958. ISSN 1078-8956. PMID 14608379. 
  6. Yuasa, K; Michibata H, Omori K, Yanaka N (Dec. 1999). «A novel interaction of cGMP-dependent protein kinase I with troponin T». J. Biol. Chem. (UNITED STATES) 274 (52):  pp. 37429–34. ISSN 0021-9258. PMID 10601315. 
  7. Ammendola, A; Geiselhöringer A, Hofmann F, Schlossmann J (Jun. 2001). «Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta». J. Biol. Chem. (United States) 276 (26):  pp. 24153–9. doi:10.1074/jbc.M101530200. ISSN 0021-9258. PMID 11309393. 
  8. Casteel, Darren E; Zhuang Shunhui, Gudi Tanima, Tang Julian, Vuica Milena, Desiderio Stephen, Pilz Renate B (Aug. 2002). «cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I». J. Biol. Chem. (United States) 277 (35):  pp. 32003–14. doi:10.1074/jbc.M112332200. ISSN 0021-9258. PMID 12082086. 

Wikimedia foundation. 2010.

Игры ⚽ Поможем сделать НИР

Mira otros diccionarios:

  • PRKG1 — Protein kinase, cGMP dependent, type I, also known as PRKG1, is a human gene.cite web | title = Entrez Gene: PRKG1 protein kinase, cGMP dependent, type I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • Protein kinase A — In cell biology, Protein kinase A (PKA) refers to a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP dependent protein kinase (EC 2.7.11.11). Protein kinase A has several functions… …   Wikipedia

  • Cyclin-dependent kinase — Schematic of the cell cycle. outer ring: I=Interphase, M=Mitosis; inner ring: M=Mitosis; G1=Gap phase 1; S=Synthesis; G2=Gap phase 2. The duration of mitosis in relation to the other phases has been exaggerated in this diagram Cyclin dependent… …   Wikipedia

  • Mitogen-activated protein kinase — Identifiers EC number 2.7.11.24 CAS number 142243 02 5 …   Wikipedia

  • Titin — The three dimensional structure of a type I module from titin. PDB rendering based on 1bpv …   Wikipedia

  • PDK1 — Not to be confused with the master kinase PDK1, 3 phosphoinositide dependent protein kinase (PDPK1). Pyruvate dehydrogenase kinase, isozyme 1 Rendering based on PDB …   Wikipedia

  • CGMP-dependent protein kinase — protein Name= protein kinase, cGMP dependent, type I caption= width= HGNCid=9414 Symbol=PRKG1 AltSymbols=PRKGR1B, PRKG1B EntrezGene=5592 OMIM=176894 RefSeq=NM 006258 UniProt=P14619 PDB= ECnumber= Chromosome=10 Arm=q Band=11.2… …   Wikipedia

  • Mammalian target of rapamycin — Mechanistic target of rapamycin (serine/threonine kinase) PDB rendering based on 1aue …   Wikipedia

  • MAP kinase kinase kinase — (or MAP3K or MEKK) is a serine/threonine specific protein kinase which acts upon MAP kinase kinase. In humans there are at least 19 genes: MAP3K1 (aka MEKK1) MAP3K2 MAP3K3 (aka MEKK3) MAP3K4 MAP3K5 (aka ASK1) MAP3K6 (aka ASK2) MAP3K7 (aka MEKK7)… …   Wikipedia

  • P70S6 kinase — or p70S6K is a serine/threonine kinase that acts downstream of PIP3 and phosphoinositide dependent kinase 1 in the PI3 kinase pathway.[1] As the name suggests, its target substrate is the S6 ribosomal protein.[2] Phosphorylation of S6 induces… …   Wikipedia

Compartir el artículo y extractos

Link directo
Do a right-click on the link above
and select “Copy Link”