TRIM28

TRIM28
Motivo tripartito 28
HUGO 16384
Símbolo TRIM28
Símbolos alt. KAP1, FLJ29029, RNF96, TF1B, TIF1B
Datos genéticos
Locus Cr. 19 q13.43
Bases de datos
Entrez 10155
OMIM 601742
RefSeq NP_005753
UniProt Q13263

Motivo tripartito 28 (TRIM28), también conocida como factor intermediario transcripcional 1β (TIF1β), es una proteína codificada en humanos por el gen trim28.[1] [2]

Contenido

Función

TRIM28 está implicado en el control transcripcional por interacción con el dominio de represión asociado a la caja Krüppel presente en multitud de factores de transcripción. La proteína se localiza en el núcleo celular y parece encontrarse asociada con regiones específicas de la cromatina. Esta proteína pertenece a la familia de motivos tripartitos. Este motivo tripartito incluye tres dominios de unión a zinc, un dominio de dedos RING, una B-box tipo 1, una B-box tipo 2 y una región de hélice superenrollada.[3]

Interacciones

La proteína TRIM28 ha demostrado ser capaz de interaccionar con:

Véase también

  • Corregulador transcripcional

Referencias

  1. ↑ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). «The tripartite motif family identifies cell compartments». Embo J. 20 (9):  pp. 2140–51. doi:10.1093/emboj/20.9.2140. PMID 11331580. 
  2. ↑ Capili AD, Schultz DC, RauscherIII FJ, Borden KL (January 2001). «Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains». Embo J. 20 (1-2):  pp. 165–77. doi:10.1093/emboj/20.1.165. PMID 11226167. 
  3. ↑ «Entrez Gene: TRIM28 tripartite motif-containing 28».
  4. ↑ Nielsen, Anders Lade; Sanchez Cecilia, Ichinose Hiroshi, Cerviño Margarita, Lerouge Thierry, Chambon Pierre, Losson Régine (Nov. 2002). «Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha». EMBO J. (England) 21 (21):  pp. 5797–806. ISSN 0261-4189. PMID 12411497. 
  5. ↑ Cammas, Florence; Oulad-Abdelghani Mustapha, Vonesch Jean-Luc, Huss-Garcia Yolande, Chambon Pierre, Losson Régine (Sep. 2002). «Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction». J. Cell. Sci. (England) 115 (Pt 17):  pp. 3439–48. ISSN 0021-9533. PMID 12154074. 
  6. ↑ Nielsen, A L; Oulad-Abdelghani M, Ortiz J A, Remboutsika E, Chambon P, Losson R (Apr. 2001). «Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins». Mol. Cell (United States) 7 (4):  pp. 729–39. ISSN 1097-2765. PMID 11336697. 
  7. ↑ Lechner, M S; Begg G E, Speicher D W, Rauscher F J (Sep. 2000). «Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential». Mol. Cell. Biol. (UNITED STATES) 20 (17):  pp. 6449–65. ISSN 0270-7306. PMID 10938122. 
  8. ↑ Moosmann, P; Georgiev O, Le Douarin B, Bourquin J P, Schaffner W (Dec. 1996). «Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1». Nucleic Acids Res. (ENGLAND) 24 (24):  pp. 4859–67. ISSN 0305-1048. PMID 9016654. 
  9. ↑ Peng, H; Begg G E, Harper S L, Friedman J R, Speicher D W, Rauscher F J (Jun. 2000). «Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain». J. Biol. Chem. (UNITED STATES) 275 (24):  pp. 18000–10. doi:10.1074/jbc.M001499200. ISSN 0021-9258. PMID 10748030. 
  10. ↑ Rooney, J W; Calame K L (Nov. 2001). «TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937». Genes Dev. (United States) 15 (22):  pp. 3023–38. doi:10.1101/gad.937201. ISSN 0890-9369. PMID 12269264. 
  11. ↑ a b Chang, C J; Chen Y L, Lee S C (Oct. 1998). «Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression». Mol. Cell. Biol. (UNITED STATES) 18 (10):  pp. 5880–7. ISSN 0270-7306. PMID 9742105. 
  12. ↑ Schultz, David C; Ayyanathan Kasirajan, Negorev Dmitri, Maul Gerd G, Rauscher Frank J (Apr. 2002). «SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins». Genes Dev. (United States) 16 (8):  pp. 919–32. doi:10.1101/gad.973302. ISSN 0890-9369. PMID 11959841. 

Enlaces externos


Wikimedia foundation. 2010.

Игры ⚽ Поможем написать реферат

Mira otros diccionarios:

  • TRIM28 — Tripartite motif containing 28, also known as TRIM28, is a human gene. PBB Summary section title = summary text = The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel associated box repression domain… …   Wikipedia

  • Transcription coregulator — In the field of molecular biology, transcription coregulators are proteins that interact with transcription factors to either activate or repress the transcription of specific genes.cite journal |author=Glass CK, Rosenfeld MG|title=The… …   Wikipedia

  • Glucocorticoid receptor — Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Crystallographic structures of the glucocorticoid receptor DNA binding domain (DBD, left, PDB 1R4O bound to DNA) and ligand bindin …   Wikipedia

  • Cumulus oophorus — Section of vesicular ovarian follicle of cat. X 50. (Discus proligerus labeled at lower left.) Gray s sub …   Wikipedia

  • CEBPB — CCAAT/enhancer binding protein (C/EBP), beta PDB rendering based on 1ci6 …   Wikipedia

  • RING finger domain — Pfam box Symbol = zf C3HC4 Name = Zinc finger, C3HC4 type (RING finger) width = caption = Pfam= PF00097 InterPro= IPR001841 SMART= PROSITE= PDOC00449 SCOP = 1chc TCDB = OPM family= OPM protein= PDB=PDB3|1jm7A:24 64 PDB3|1rmd :290 328 PDB3|1bor… …   Wikipedia

  • Tripartite motif family — The tripartite motif family is a protein family.cite journal |author=Reymond A, Meroni G, Fantozzi A, et al |title=The tripartite motif family identifies cell compartments |journal=EMBO J. |volume=20 |issue=9 |pages=2140–51 |year=2001… …   Wikipedia

  • ZNF10 — Proteína de dedos de zinc 10 HUGO 12879 Símbolo ZNF10 Símbolos alt. KOX1 …   Wikipedia Español

Compartir el artículo y extractos

Link directo
… Do a right-click on the link above
and select “Copy Link”