GATA4

GATA4
Proteína de unión GATA4
HUGO 4173
Símbolo GATA4
Símbolos alt. MGC126629
Datos genéticos
Locus Cr. 8 p23.1
Bases de datos
Entrez 2626
OMIM 600576
RefSeq NP_002043
UniProt P43694

La proteína GATA4 es un factor de transcripción codificado en humanos por el gen gata4.[1]

La proteína GATA4 pertenece a la familia de factores de transcripción GATA con dominios de dedos de zinc. Los miembros de esta familia reconocen el motivo de ADN GATA, que está presente en los promotores de multitud de genes. GATA4 parece regular genes implicados en embriogénesis y en la diferenciación y función del miocardio. Se han asociado mutaciones en este gen con defectos del septum arteriosum.[2]

Contenido

Interacciones

La proteína GATA4 ha demostrado ser capaz de interaccionar con:

Véase también

Referencias

  1. ↑ White RA, Dowler LL, Pasztor LM, Gatson LL, Adkison LR, Angeloni SV, Wilson DB (Oct 1995). «Assignment of the transcription factor GATA4 gene to human chromosome 8 and mouse chromosome 14: Gata4 is a candidate gene for Ds (disorganization)». Genomics 27 (1):  pp. 20–6. doi:10.1006/geno.1995.1003. PMID 7665171. 
  2. ↑ «Entrez Gene: GATA4 GATA binding protein 4».
  3. ↑ a b Garg, Vidu; Kathiriya Irfan S, Barnes Robert, Schluterman Marie K, King Isabelle N, Butler Cheryl A, Rothrock Caryn R, Eapen Reenu S, Hirayama-Yamada Kayoko, Joo Kunitaka, Matsuoka Rumiko, Cohen Jonathan C, Srivastava Deepak (Jul. 2003). «GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5». Nature (England) 424 (6947):  pp. 443–7. doi:10.1038/nature01827. PMID 12845333. 
  4. ↑ Durocher, D; Charron F, Warren R, Schwartz R J, Nemer M (Sep. 1997). «The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors». EMBO J. (ENGLAND) 16 (18):  pp. 5687–96. doi:10.1093/emboj/16.18.5687. ISSN 0261-4189. PMID 9312027. 
  5. ↑ Zhu, W; Shiojima I, Hiroi Y, Zou Y, Akazawa H, Mizukami M, Toko H, Yazaki Y, Nagai R, Komuro I (Nov. 2000). «Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease». J. Biol. Chem. (UNITED STATES) 275 (45):  pp. 35291–6. doi:10.1074/jbc.M000525200. ISSN 0021-9258. PMID 10948187. 
  6. ↑ Svensson, E C; Tufts R L, Polk C E, Leiden J M (Feb. 1999). «Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (3):  pp. 956–61. ISSN 0027-8424. PMID 9927675. 
  7. ↑ Belaguli, N S; Sepulveda J L, Nigam V, Charron F, Nemer M, Schwartz R J (Oct. 2000). «Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators». Mol. Cell. Biol. (UNITED STATES) 20 (20):  pp. 7550–8. ISSN 0270-7306. PMID 11003651. 
  8. ↑ Morin, S; Paradis P, Aries A, Nemer M (Feb. 2001). «Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor». Mol. Cell. Biol. (United States) 21 (4):  pp. 1036–44. doi:10.1128/MCB.21.4.1036-1044.2001. ISSN 0270-7306. PMID 11158291. 
  9. ↑ Dai, Yan-Shan; Cserjesi Peter, Markham Bruce E, Molkentin Jeffery D (Jul. 2002). «The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism». J. Biol. Chem. (United States) 277 (27):  pp. 24390–8. doi:10.1074/jbc.M202490200. ISSN 0021-9258. PMID 11994297. 

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