MCM7

MCM7
Proteína 7 de mantenimiento de mini-cromosomas (S. cerevisiae)
HUGO 6950
Símbolo MCM7
Símbolos alt. MCM2; CDABP0042; CDC47; P1.1-MCM3; P1CDC47; P85MCM; PNAS-146
Datos genéticos
Locus Cr. 7 q22.1
Bases de datos
Entrez 4176
OMIM 600592
RefSeq NP_005907
UniProt P33993

La proteína 7 de mantenimiento de mini-cromosomas (MCM7) es una proteína codificada en humanos por el gen MCM7.[1]

La proteína codificada por este gen es una de las implicadas en el mantenimiento de mini-cromosomas (MCM), que son esenciales para el inicio de la replicación del genoma eucariota. Las proteínas MCM forman un complejo hexamérico que es un componente clave del complejo pre-replicativo (pre-RC) y podría estar implicado en la formación de las horquillas de replicación y en el reclutamiento de otras proteínas asociadas a la replicación del ADN. La proteína MCM7, junto a MCM2, MCM4 y MCM6, poseen actividad ADN-helicasa, por lo que podrían actuar como enzimas de desenrollamiento del ADN. La proteína Cdk4 se encuentra asociada a MCM7 y podría regular su unión a la proteína supresora de tumores RB1/RB. Se han descrito diversas variantes transcripcionales de este gen, que codifican diferentes isoformas de la proteína.[2]

Interacciones

La proteína MCM7 ha demostrado ser capaz de interaccionar con:

Véase también

  • Complejo de mantenimiento de mini-cromosomas

Referencias

  1. ↑ Nakatsuru S, Sudo K, Nakamura Y (Mar 1995). «Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication». Cytogenet Cell Genet 68 (3-4):  pp. 226–30. PMID 7842741. 
  2. ↑ «Entrez Gene: MCM7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)».
  3. ↑ a b c d e f g h i j k l m Kneissl, Margot; Pütter Vera, Szalay Aladar A, Grummt Friedrich (Mar. 2003). «Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells». J. Mol. Biol. (England) 327 (1):  pp. 111–28. ISSN 0022-2836. PMID 12614612. 
  4. ↑ Sterner, J M; Dew-Knight S, Musahl C, Kornbluth S, Horowitz J M (May. 1998). «Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7». Mol. Cell. Biol. (UNITED STATES) 18 (5):  pp. 2748–57. ISSN 0270-7306. PMID 9566894. 
  5. ↑ a b c d e Fujita, M; Kiyono T, Hayashi Y, Ishibashi M (Apr. 1997). «In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP». J. Biol. Chem. (UNITED STATES) 272 (16):  pp. 10928–35. ISSN 0021-9258. PMID 9099751. 
  6. ↑ DaFonseca, C J; Shu F, Zhang J J (Mar. 2001). «Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma». Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (6):  pp. 3034–9. doi:10.1073/pnas.061487598. ISSN 0027-8424. PMID 11248027. 
  7. ↑ a b c Yabuta, Norikazu; Kajimura Naoko, Mayanagi Kouta, Sato Michio, Gotow Takahito, Uchiyama Yasuo, Ishimi Yukio, Nojima Hiroshi (May. 2003). «Mammalian Mcm2/4/6/7 complex forms a toroidal structure». Genes Cells (England) 8 (5):  pp. 413–21. ISSN 1356-9597. PMID 12694531. 
  8. ↑ a b c You, Zhiying; Ishimi Yukio, Masai Hisao, Hanaoka Fumio (Nov. 2002). «Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex». J. Biol. Chem. (United States) 277 (45):  pp. 42471–9. doi:10.1074/jbc.M205769200. ISSN 0021-9258. PMID 12207017. 
  9. ↑ Ishimi, Y; Ichinose S, Omori A, Sato K, Kimura H (Sep. 1996). «Binding of human minichromosome maintenance proteins with histone H3». J. Biol. Chem. (UNITED STATES) 271 (39):  pp. 24115–22. ISSN 0021-9258. PMID 8798650. 
  10. ↑ a b Fujita, M; Yamada C, Goto H, Yokoyama N, Kuzushima K, Inagaki M, Tsurumi T (Sep. 1999). «Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation». J. Biol. Chem. (UNITED STATES) 274 (36):  pp. 25927–32. ISSN 0021-9258. PMID 10464337. 
  11. ↑ Fujita, Masatoshi; Ishimi Yukio, Nakamura Hiromu, Kiyono Tohru, Tsurumi Tatsuya (Mar. 2002). «Nuclear organization of DNA replication initiation proteins in mammalian cells». J. Biol. Chem. (United States) 277 (12):  pp. 10354–61. doi:10.1074/jbc.M111398200. ISSN 0021-9258. PMID 11779870. 
  12. ↑ Wang, Y; Xu F, Hall F L (Oct. 2000). «The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor». FEBS Lett. (NETHERLANDS) 484 (1):  pp. 17–21. ISSN 0014-5793. PMID 11056214. 
  13. ↑ You, Z; Komamura Y, Ishimi Y (Dec. 1999). «Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity». Mol. Cell. Biol. (UNITED STATES) 19 (12):  pp. 8003–15. ISSN 0270-7306. PMID 10567526. 
  14. ↑ Kühne, C; Banks L (Dec. 1998). «E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box». J. Biol. Chem. (UNITED STATES) 273 (51):  pp. 34302–9. ISSN 0021-9258. PMID 9852095. 
  15. ↑ Kukimoto, I; Igaki H, Kanda T (Nov. 1999). «Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha». Eur. J. Biochem. (GERMANY) 265 (3):  pp. 936–43. ISSN 0014-2956. PMID 10518787. 

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