- TAL1
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Proteína 1 de leucemia linfoide aguda de células T HUGO 11556 Símbolo TAL1 Símbolos alt. SCL, TCL5, tal-1 Datos genéticos Locus Cr. 1 p33 Bases de datos Entrez 6886 OMIM 187040 RefSeq NP_003180 UniProt P17542 La proteína 1 de leucemia linfoide aguda de células T es una proteína codificada en humanos por el gen tal1.[1] [2] TAL1 es un factor de transcripción con un dominio hélice-bucle-hélice implicada, cuando está truncada o ausente, en el desarrollo de leucemia linfoide aguda de células T.
Interacciones
La proteína TAL1 ha demostrado ser capaz de interaccionar con:
- LMO1[3] [4]
- LDB1[5]
- SIN3A[6]
- LMO2[4] [3] [5] [7]
- Sp1[8]
- TCF3[5] [9]
- CBFA2T3[5]
- EP300[10]
- GATA1[5] [7]
Referencias
- ↑ Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM (Aug 1989). «Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma». Proc Natl Acad Sci U S A 86 (13): pp. 5039–43. PMID 2740341.
- ↑ «Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1».
- ↑ a b Valge-Archer, V E; Osada H, Warren A J, Forster A, Li J, Baer R, Rabbitts T H (Aug. 1994). «The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (18): pp. 8617–21. ISSN 0027-8424. PMID 8078932.
- ↑ a b Wadman, I; Li J, Bash R O, Forster A, Osada H, Rabbitts T H, Baer R (Oct. 1994). «Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia». EMBO J. (ENGLAND) 13 (20): pp. 4831–9. ISSN 0261-4189. PMID 7957052.
- ↑ a b c d e Goardon, Nicolas; Lambert Julie A, Rodriguez Patrick, Nissaire Philippe, Herblot Sabine, Thibault Pierre, Dumenil Dominique, Strouboulis John, Romeo Paul-Henri, Hoang Trang (Jan. 2006). «ETO2 coordinates cellular proliferation and differentiation during erythropoiesis». EMBO J. (England) 25 (2): pp. 357–66. doi:. ISSN 0261-4189. PMID 16407974.
- ↑ Huang, S; Brandt S J (Mar. 2000). «mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor». Mol. Cell. Biol. (UNITED STATES) 20 (6): pp. 2248–59. ISSN 0270-7306. PMID 10688671.
- ↑ a b Osada, H; Grutz G, Axelson H, Forster A, Rabbitts T H (Oct. 1995). «Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (21): pp. 9585–9. ISSN 0027-8424. PMID 7568177.
- ↑ Lécuyer, Eric; Herblot Sabine, Saint-Denis Marianne, Martin Richard, Begley C Glenn, Porcher Catherine, Orkin Stuart H, Hoang Trang (Oct. 2002). «The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1». Blood (United States) 100 (7): pp. 2430–40. doi:. ISSN 0006-4971. PMID 12239153.
- ↑ Hsu, H L; Wadman I, Baer R (Apr. 1994). «Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (8): pp. 3181–5. ISSN 0027-8424. PMID 8159721.
- ↑ Huang, S; Qiu Y, Stein R W, Brandt S J (Sep. 1999). «p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein». Oncogene (ENGLAND) 18 (35): pp. 4958–67. doi:. ISSN 0950-9232. PMID 10490830.
Enlaces externos
Categorías:- Genes del cromosoma 1
- Factores de transcripción
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