- GCN5L2
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Histona acetiltransferasa KAT2A 
Estructura tridimensional de la proteína GCN5L2.HUGO 4201 Símbolo GCN5L2 Símbolos alt. GCN5; MGC102791; PCAF-b; hGCN5 Datos genéticos Locus Cr. 17 q21.2 Bases de datos Entrez 2648 OMIM 602301 PDB 1f68 RefSeq NP_066564 UniProt Q92830 La histona acetiltransferasa KAT2A (GCN5L2) es una enzima con actividad histona acetiltransferasa codificada en humanos por el gen KAT2A.[1] [2]
Interacciones
La proteína GCN5L2 ha demostrado ser capaz de interaccionar con:
Referencias
- ↑ Candau R, Moore PA, Wang L, Barlev N, Ying CY, Rosen CA, Berger SL (Feb 1996). «Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5». Mol Cell Biol 16 (2): pp. 593–602. PMID 8552087.
- ↑ «Entrez Gene: GCN5L2 GCN5 general control of amino-acid synthesis 5-like 2 (yeast)».
- ↑ a b c Barlev, N A; Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman J L, Berger S L (Mar. 1998). «Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex». Mol. Cell. Biol. (UNITED STATES) 18 (3): pp. 1349–58. ISSN 0270-7306. PMID 9488450.
- ↑ a b c Martinez, E; Palhan V B, Tjernberg A, Lymar E S, Gamper A M, Kundu T K, Chait B T, Roeder R G (Oct. 2001). «Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo». Mol. Cell. Biol. (United States) 21 (20): pp. 6782–95. doi:. ISSN 0270-7306. PMID 11564863.
- ↑ Brand, M; Moggs J G, Oulad-Abdelghani M, Lejeune F, Dilworth F J, Stevenin J, Almouzni G, Tora L (Jun. 2001). «UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation». EMBO J. (England) 20 (12): pp. 3187–96. doi:. ISSN 0261-4189. PMID 11406595.
- ↑ Wang, L; Mizzen C, Ying C, Candau R, Barlev N, Brownell J, Allis C D, Berger S L (Jan. 1997). «Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation». Mol. Cell. Biol. (UNITED STATES) 17 (1): pp. 519–27. ISSN 0270-7306. PMID 8972232.
Categorías:- Genes del cromosoma 17
- Proteínas humanas
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