NUMB

NUMB
Protein numb homolog
Protein NUMB PDB 1wj1.png
Estructura tridimensional de la proteína NUMB.
HUGO 8060
Símbolo NUMB
Símbolos alt. S171
Datos genéticos
Locus Cr. 14 q24.2-q24.3
Bases de datos
Entrez 8650
OMIM 603728
PDB 1wj1
RefSeq NP_001005743
UniProt P49757

La proteína numb homolog (NUMB) es una proteína codificada en humanos por el gen NUMB.

La proteína NUMB juega un papel importante en la determinación del destino celular durante el desarrollo. Esta proteína, cuya degradación es inducida por Mdm2 de un modo dependiente de proteasoma, es una proteína unida a membrana que ha demostrado estar asociada con EPS15, LNX1 y NOTCH1. Se han descrito cuatro variantes transcripcionales del gen que codifican diferentes isoformas de la proteína.[1]

Interacciones

La proteína NUMB ha demostrado ser capaz de interaccionar con:

Referencias

  1. ↑ «Entrez Gene: NUMB numb homolog (Drosophila)».
  2. ↑ a b c Nishimura, Takashi; Fukata Yuko, Kato Katsuhiro, Yamaguchi Tomoya, Matsuura Yoshiharu, Kamiguchi Hiroyuki, Kaibuchi Kozo (Sep. 2003). «CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth». Nat. Cell Biol. (England) 5 (9):  pp. 819–26. doi:10.1038/ncb1039. ISSN 1465-7392. PMID 12942088. 
  3. ↑ Yogosawa, Satomi; Miyauchi Yasuhiro, Honda Reiko, Tanaka Hirofumi, Yasuda Hideyo (Mar. 2003). «Mammalian Numb is a target protein of Mdm2, ubiquitin ligase». Biochem. Biophys. Res. Commun. (United States) 302 (4):  pp. 869–72. ISSN 0006-291X. PMID 12646252. 
  4. ↑ a b Colaluca, Ivan N; Tosoni Daniela, Nuciforo Paolo, Senic-Matuglia Francesca, Galimberti Viviana, Viale Giuseppe, Pece Salvatore, Di Fiore Pier Paolo (Jan. 2008). «NUMB controls p53 tumour suppressor activity». Nature (England) 451 (7174):  pp. 76–80. doi:10.1038/nature06412. PMID 18172499. 
  5. ↑ Susini, L; Passer B J, Amzallag-Elbaz N, Juven-Gershon T, Prieur S, Privat N, Tuynder M, Gendron M C, Israël A, Amson R, Oren M, Telerman A (Dec. 2001). «Siah-1 binds and regulates the function of Numb». Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (26):  pp. 15067–72. doi:10.1073/pnas.261571998. ISSN 0027-8424. PMID 11752454. 
  6. ↑ Nie, Jing; McGill Melanie A, Dermer Matt, Dho Sascha E, Wolting Cheryl D, McGlade C Jane (Jan. 2002). «LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation». EMBO J. (England) 21 (1-2):  pp. 93–102. doi:10.1093/emboj/21.1.93. ISSN 0261-4189. PMID 11782429. 

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