Histona deacetilasa 1

Histona deacetilasa 1
Histona deacetilasa 1
HUGO 4852
Símbolo HDAC1
Símbolos alt. DKFZp686H12203; GON-10; HD1; RPD3; RPD3L1
Datos genéticos
Locus Cr. 1 p35.1
Bases de datos
Entrez 3065
OMIM 601241
RefSeq NP_004955
UniProt Q13547

La histona deacetilasa 1 (HDAC1) es una enzima codificada en humanos por el gen hdac1.[1]

Contenido

Función

Las histonas juegan un papel crucial en la regulación de la transcripción, en la progresión del ciclo celular y en procesos de desarrollo. La acetilación/desacetilación de histonas altera la estructura del cromosoma, variando así la accesibilidad de los factores de transcripción al ADN. La HDAC1 pertenece a la familia de histona deacetilasas acuc/alfa y es uno de los componentes del complejo histona deacetilasa. Esta proteína interacciona con la proteína del retinoblastoma formando un complejo que es un elemento clave en el control de la proliferación celular y la diferenciación celular. Junto con la proteína 2 asociada a metástasis, deacetila a p53 y modula su acción sobre la proliferación celular y la apoptosis.[2]

Interacciones

La histona deacetilasa 1 ha demostrado ser capaz de interaccionar con:

Véase también

Referencias

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